Background Tumour hypoxia is a driver of breast cancer progression associated with worse
prognosis and more aggressive disease. The cellular response to hypoxia is mediated by …

Oestrogen receptor α (ERα) is a nuclear receptor that is the driving transcription factor
expressed in the majority of breast cancers. Recent studies have demonstrated that the liver …

Expression of estrogen-related receptor α (ERRα) has recently been shown to carry
negative prognostic significance in breast and ovarian cancers. The specific role of this …

Recent human studies found that the mRNA expression level of aryl-hydrocarbon receptor
nuclear translocator 2 (ARNT2) was positively associated with the prognosis of breast …

Resistance to hormonal therapy frequently occurs following successful treatment in breast
cancer. The mechanism responsible for this acquired resistance is still unknown. It has been …

Estrogen-related receptor alpha (ERRα) is an orphan member of the nuclear receptor family
of transcription factors. In addition to its function as a metabolic regulator, ERRα has been …

Abstract Estrogen-related receptors (ERR), ERR alpha (ERRα) and ERR gamma (ERRγ),
are orphan nuclear receptors implicated in breast cancer that function similarly in the …

The aryl hydrocarbon receptor nuclear translocator (ARNT) is a basic helix-loop-helix
transcription factor that forms heterodimers with the aryl hydrocarbon receptor (AhR) or …

Estrogen receptor-α (ER) is expressed in the great majority of breast cancers, and the
inhibition of ER action is a key part of breast cancer treatment. The inhibition of ER action is …

Background Breast cancer (BC) is highly heterogeneous with~ 60–70% of estrogen receptor
positive BC patient's response to anti-hormone therapy. Estrogen receptors (ERs) play an …