CNS repurposing-Potential new uses for old drugs: examples of screens for Alzheimer's disease, Parkinson's disease and spasticity

CG Parsons - Neuropharmacology, 2019 - Elsevier
Drug repurposing is recently gaining increasing attention, not just from pharmaceutical
companies but also from government agencies in an attempt to generate new medications to …

Drug repurposing in neurological diseases: an integrated approach to reduce trial and error

AE Clout, O Della Pasqua, MG Hanna… - Journal of Neurology …, 2019 - jnnp.bmj.com
Identifying effective disease-modifying therapies for neurological diseases remains an
important challenge in drug discovery and development. Drug repurposing attempts to …

Drug repurposing strategies of relevance for Parkinson's disease

EJR Fletcher, T Kaminski, G Williams… - Pharmacology …, 2021 - Wiley Online Library
Parkinson's disease is a highly disabling, progressive neurodegenerative disease that
manifests as a mix of motor and non‐motor signs. Although we are equipped with some …

Discovering new treatments for Alzheimer's disease by repurposing approved medications

BS Appleby, JL Cummings - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is the most common cause of dementia and a major cause of
morbidity and mortality. The greatest risk factor for AD is age and as many countries are …

Old drugs as new treatments for neurodegenerative diseases

F Durães, M Pinto, E Sousa - Pharmaceuticals, 2018 - mdpi.com
Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …

Drug repurposing: far beyond new targets for old drugs

TI Oprea, J Mestres - The AAPS journal, 2012 - Springer
Repurposing drugs requires finding novel therapeutic indications compared to the ones for
which they were already approved. This is an increasingly utilized strategy for finding novel …

Recent advances in drug repurposing for Parkinson's disease

X Chen, G Gumina, KG Virga - Current Medicinal Chemistry, 2019 - ingentaconnect.com
As a long-term degenerative disorder of the central nervous system that mostly affects older
people, Parkinson's disease is a growing health threat to our ever-aging population. Despite …

The potential of a stratified approach to drug repurposing in Alzheimer's disease

C Anderson, M Bucholc, PL McClean, SD Zhang - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative condition that is characterized by
the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories …

[HTML][HTML] Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders

DK Khatri, A Kadbhane, M Patel, S Nene… - Current Research in …, 2021 - Elsevier
Neurodegenerative diseases (ND) are of vast origin which are characterized by gradual
progressive loss of neurons in the brain region. ND can be classified according to the …

Tackling Alzheimer's Disease with Existing Drugs: A Promising Strategy for Bypassing Obstacles

A Rampa, S Gobbi, F Belluti… - Current Medicinal …, 2021 - ingentaconnect.com
The unmet need for the development of effective drugs to treat Alzheimer's disease has
been steadily growing, representing a major challenge in drug discovery. In this context …