CNS repurposing-Potential new uses for old drugs: examples of screens for Alzheimer's disease, Parkinson's disease and spasticity
CG Parsons - Neuropharmacology, 2019 - Elsevier
Drug repurposing is recently gaining increasing attention, not just from pharmaceutical
companies but also from government agencies in an attempt to generate new medications to …
companies but also from government agencies in an attempt to generate new medications to …
Drug repurposing in neurological diseases: an integrated approach to reduce trial and error
Identifying effective disease-modifying therapies for neurological diseases remains an
important challenge in drug discovery and development. Drug repurposing attempts to …
important challenge in drug discovery and development. Drug repurposing attempts to …
Drug repurposing strategies of relevance for Parkinson's disease
EJR Fletcher, T Kaminski, G Williams… - Pharmacology …, 2021 - Wiley Online Library
Parkinson's disease is a highly disabling, progressive neurodegenerative disease that
manifests as a mix of motor and non‐motor signs. Although we are equipped with some …
manifests as a mix of motor and non‐motor signs. Although we are equipped with some …
Discovering new treatments for Alzheimer's disease by repurposing approved medications
BS Appleby, JL Cummings - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is the most common cause of dementia and a major cause of
morbidity and mortality. The greatest risk factor for AD is age and as many countries are …
morbidity and mortality. The greatest risk factor for AD is age and as many countries are …
Old drugs as new treatments for neurodegenerative diseases
F Durães, M Pinto, E Sousa - Pharmaceuticals, 2018 - mdpi.com
Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …
population is becoming older. They manifest themselves through mechanisms that are not …
Drug repurposing: far beyond new targets for old drugs
Repurposing drugs requires finding novel therapeutic indications compared to the ones for
which they were already approved. This is an increasingly utilized strategy for finding novel …
which they were already approved. This is an increasingly utilized strategy for finding novel …
Recent advances in drug repurposing for Parkinson's disease
X Chen, G Gumina, KG Virga - Current Medicinal Chemistry, 2019 - ingentaconnect.com
As a long-term degenerative disorder of the central nervous system that mostly affects older
people, Parkinson's disease is a growing health threat to our ever-aging population. Despite …
people, Parkinson's disease is a growing health threat to our ever-aging population. Despite …
The potential of a stratified approach to drug repurposing in Alzheimer's disease
C Anderson, M Bucholc, PL McClean, SD Zhang - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative condition that is characterized by
the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories …
the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories …
[HTML][HTML] Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders
Neurodegenerative diseases (ND) are of vast origin which are characterized by gradual
progressive loss of neurons in the brain region. ND can be classified according to the …
progressive loss of neurons in the brain region. ND can be classified according to the …
Tackling Alzheimer's Disease with Existing Drugs: A Promising Strategy for Bypassing Obstacles
A Rampa, S Gobbi, F Belluti… - Current Medicinal …, 2021 - ingentaconnect.com
The unmet need for the development of effective drugs to treat Alzheimer's disease has
been steadily growing, representing a major challenge in drug discovery. In this context …
been steadily growing, representing a major challenge in drug discovery. In this context …