Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1
S Paschoud, AM Dogar, C Kuntz… - … and cellular biology, 2006 - Am Soc Microbiol
Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …
[HTML][HTML] p38α stabilizes Interleukin-6 mRNA via multiple AU-richElements
AU-rich elements (AREs) in the 3′-untranslated region (UTR) ofunstable mRNA dictate
their degradation or mediate translational repression. Cell signaling through p38α MAPK is …
their degradation or mediate translational repression. Cell signaling through p38α MAPK is …
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets
R Winzen, BK Thakur, O Dittrich-Breiholz… - … and cellular biology, 2007 - Taylor & Francis
mRNA stability is a major determinant of inflammatory gene expression. Rapid degradation
of interleukin-8 (IL-8) mRNA is imposed by a bipartite AU-rich element (ARE) in the 3 …
of interleukin-8 (IL-8) mRNA is imposed by a bipartite AU-rich element (ARE) in the 3 …
Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR
R Winzen, G Gowrishankar, F Bollig… - … and cellular biology, 2004 - Taylor & Francis
AU-rich elements (AREs) control the expression of numerous genes by accelerating the
decay of their mRNAs. Rapid decay and deadenylation of β-globin mRNA containing AU …
decay of their mRNAs. Rapid decay and deadenylation of β-globin mRNA containing AU …
Sustained stabilization of Interleukin-8 mRNA in human macrophages
L Mahmoud, F Al-Enezi, M Al-Saif, A Warsy… - RNA biology, 2014 - Taylor & Francis
The mRNAs of most inflammatory mediators are short-lived due to AU-rich elements (AREs)
in their 3′-untranslated regions. AREs ensure a low basal level of expression during …
in their 3′-untranslated regions. AREs ensure a low basal level of expression during …
Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region
MJ Powell, SAJ Thompson, Y Tone… - The Journal of …, 2000 - journals.aai.org
Abstract IL-10 is an 18-kDa immunoregulatory cytokine the transcription of which is
controlled by the ubiquitously expressed transcription factors Sp1 and Sp3. Although many …
controlled by the ubiquitously expressed transcription factors Sp1 and Sp3. Although many …
Increased interleukin-10 mRNA stability in melanoma cells is associated with decreased levels of A+ U-rich element binding factor AUF1
Abnormal production of interleukin-10 (IL-10) is observed in some pathologic conditions. For
example, compared with normal melanocytes, IL-10 expression is elevated in melanoma …
example, compared with normal melanocytes, IL-10 expression is elevated in melanoma …
Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Localization of an instability determinant to a cluster of AUUUA motifs.
M Gorospe, C Baglioni - Journal of Biological Chemistry, 1994 - ASBMB
Labeled transcripts of interleukin-1 alpha (IL-1 alpha) cDNA were rapidly degraded in
incubations with rabbit reticulocyte lysate (RRL). In contrast, a transcript of superoxide …
incubations with rabbit reticulocyte lysate (RRL). In contrast, a transcript of superoxide …
Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
P Bufler, F Gamboni-Robertson, T Azam… - Biochemical …, 2004 - portlandpress.com
IL-1F7b, a novel homologue of the IL-1 (interleukin 1) family, was discovered by
computational cloning. We demonstrated that IL-1F7b shares critical amino acid residues …
computational cloning. We demonstrated that IL-1F7b shares critical amino acid residues …
Functional hierarchy of AUUUA motifs in mediating rapid interleukin-3 mRNA decay.
G Stoecklin, S Hahn, C Moroni - Journal of Biological Chemistry, 1994 - ASBMB
In mast cells, expression of interleukin-3 (IL-3) is induced following IgE-receptor activation
via calcium-dependent mRNA stabilization. We performed a mutational analysis of the 8 …
via calcium-dependent mRNA stabilization. We performed a mutational analysis of the 8 …