Revised Manuscript Received October 27, 1986 abstract: The Ca2+/phosphatidylserine-
stimulated protein kinase C (PKC) appears to exist as interconvertible inactive, soluble and …

Immunological analysis using monoclonal antibodies against subspecies of protein kinase
C revealed the predominant expression of the isozyme, type II, in human megakaryoblastic …

The effect of phorbol 12-myristate 13-acetate (PMA) on protein kinase C was studied by
metabolically labeling GH3 cells with [35S] methionine and using a polyclonal antibody …

The effects of phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on the directions of
protein kinase C (PKC) translocation in two leukemic cell lines (HL60 and K562) and two …

Protein kinase C (PKC) activity of cytosol and membrane fractions of 10T cells was studied.
In cytosol of fast growing cells PKC activity was found in material eluted with 0.150 M NaCl …

Incubation of purified protein kinase C (PKC) with phospholipid vesicles produced two
populations of membrane-bound PKC: one population was dissociated by calcium chelation …

The cell-permeable inhibitors of type 1 and 2A protein phosphatases, okadaic acid and
calyculin-A, induced a redistribution of protein kinase C (PKC) activity and immunoreactivity …

The intracellular translocation of protein kinase C (PKC) from the soluble to the membranous
fraction has been shown previously to correlate with biological activity of phorbol esters in …

Department of Biochemistry, University of Minnesota, St. Paul, Minnesota 55108 Received
June 16, 1988; Revised Manuscript Received August 1, 1988 abstract: Protein kinase C …

We investigated the hypothesis that the antiproliferative effect of hexadecylphosphocholine
(HePC) and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH 3) is …