Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial

S Manglik, E Flores, L Lubarsky, F Fernandez… - Critical care …, 2003 - journals.lww.com
Glucocorticoid insufficiency in patients who present to the... : Critical Care Medicine
Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: A …

Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity

J Cohen, CJ Pretorius, JPJ Ungerer… - Critical Care …, 2016 - journals.lww.com
Objectives: To measure tissue glucocorticoid sensitivity in patients with septic shock and
determine its relationship to standard measurements of adrenal function and of outcome …

Corticosteroids in septic shock: Resurrection of the last rites

I Matot, CL Sprung - Critical care medicine, 1998 - journals.lww.com
The use of corticosteroids in patients with sepsis and septic shock has been controversial for
decades [1]. Based primarily on the Schumer study [2], high doses of glucocorticoids …

Glucocorticoids in the treatment of severe sepsis and septic shock

D Annane - Current opinion in critical care, 2005 - journals.lww.com
In septic shock, intravenous hydrocortisone should be started immediately after a 250 μg
corticotropin test, at a dose of 200-300 mg per day. When adrenal insufficiency is confirmed …

Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force …

PE Marik, SM Pastores, D Annane… - Critical care …, 2008 - journals.lww.com
Objective: To develop consensus statements for the diagnosis and management of
corticosteroid insufficiency in critically ill adult patients. Participants: A multidisciplinary …

Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock

MFC De Jong, A Beishuizen, JJ Spijkstra… - Critical care …, 2007 - journals.lww.com
Objective: To evaluate the concept of relative adrenal insufficiency necessitating
corticosteroid therapy in septic shock. Design: Retrospective study. Setting: Medical-surgical …

Corticosteroids for septic shock

D Annane - Critical care medicine, 2001 - journals.lww.com
Corticosteroids for septic shock : Critical Care Medicine Corticosteroids for septic shock :
Critical Care Medicine SCCM Pediatric Critical Care Medicine Critical Care Explorations Log …

Corticosteroid insufficiency in acutely ill patients

MS Cooper, PM Stewart - New England Journal of Medicine, 2003 - Mass Medical Soc
Recent studies report benefits from corticosteroid treatment in patients with septic shock.
This review summarizes the physiology of the corticosteroid response in acute illness. The …

Critical illness-related corticosteroid insufficiency

PE Marik - Chest, 2009 - Elsevier
The diagnosis of adrenal failure and the indications for corticosteroid therapy in critically ill
patients are controversial. This controversy is fueled by the complexity of the issues and the …

Glucocorticoid treatment of sepsis and acute respiratory distress syndrome: time for a critical reappraisal

GU Meduri, S Kanangat - Critical care medicine, 1998 - journals.lww.com
The randomized study conducted by Dr. Bollaert and colleagues [1] apparently contradicts
previous large, randomized, multicenter trials investigating sepsis and early acute …