Familial breast cancer has been recognised for many years. In the 1990s the genetic
mechanism of inheritance of a proportion of these familial cancers was found to be …

Several studies have demonstrated that familial breast cancers associated with BRCA1 or
BRCA2 germline mutations differ in their morphological and immunohistochemical …

Breast cancers arising in carriers of mutations in the breast cancer susceptibility genes,
BRCA1 and BRCA2, differ histologically from each other and from breast cancers …

Of all breast cancer cases, 5-10% can be attributed to germline mutations, and the high-
susceptibility genes BRCA1 and BRCA2 account for about 25-28% of these cases. For the …

A family history for breast cancer appears to be a major risk factor for breast cancer. It has
been estimated that 5% of all breast cancers are hereditary. In the last five years much …

Hereditary breast carcinomas constitute about 10% of all malignant mammary tumors, but
the selection criteria to identify a high‐risk population carrying BRCA1 mutations are not yet …

A small proportion of breast cancers are due to a heritable predisposition. Recently, two
predisposition genes, BRCA1 and BRCA2, have been identified and cloned. The …

Hereditary breast cancer arising in carriers of mutations in the BRCA1 and BRCA2 genes
differs from sporadic breast cancer and from non-BRCA1/2 familial breast carcinomas. Most …

Abstract Approximately 2% to 5% of all breast cancers are hereditary, meaning that the
cancer predisposition is carried as a monogenic trait. Several highly penetrant breast cancer …

Patients with germline mutations in BRCA1 or BRCA2 genes are predisposed to breast
cancer. The BRCA1-associated breast cancers have distinct morphology, being more often …