Aims To detect specific oculomotor deficits in preclinical stage of spinocerebellar ataxia type
3 (SCA 3) and evaluate whether these abnormalities prove useful as potential biomarkers of …

Background Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant cerebellar
ataxia caused by CAG trinucleotide expansion. The characteristics of regional cerebral …

Objective: To evaluate the usefulness of functional measures in patients with
spinocerebellar ataxia (SCA). Methods: We assessed three functional measures—8 m …

Fatigue has been described in several neurodegenerative diseases, reducing quality of life.
A systematic evaluation of this clinical feature is lacking in SCA3/MJD. The aim of this study …

Objective Machado–Joseph disease (SCA3/MJD) is the most frequent spinocerebellar
ataxia worldwide and characterized by brainstem, basal ganglia, and cerebellar damage …

Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases
that selectively affect vulnerable neuronal populations in the cerebellum and other …

OBJECTIVE Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant cerebellar
ataxia (ADCA) of which the mutation causing the disease has recently been characterised …

Background Only a few prospective studies have determined which clinical symptoms and
factors are associated with the disease severity of spinocerebellar ataxia type 6 (SCA6). A …

BACKGROUND AND PURPOSE: Cerebellar and brain stem atrophy are important features
in SCA3, whereas SCA6 has been regarded as a “pure” cerebellar disease. However …

Objective: To characterize the clinical and neuroradiologic features of a new spinocerebellar
ataxia, SCA-12, in the index family. Background: The authors recently linked SCA-12 to a …