Abstract The kidneys compose approximately 0.5% of the body mass but consume about
10% of the oxygen in cellular respiration. This discordance is due to the high energy …

The kidney is a highly metabolic organ that requires substantial adenosine triphosphate for
the active transport required to maintain water and solute reabsorption. Aberrations in …

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and
health care expenditure. In the United States alone, it is estimated that more than $10 billion …

Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …

While mitochondrial dysfunction is a pathological process that occurs after acute kidney
injury (AKI), the state of mitochondrial homeostasis during the injury and recovery phases of …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

Recent findings from human and experimental septic AKI studies strongly implicate the
mitochondrion as an important target for sublethal kidney injury. Stimulating the natural …

Acute kidney injury (AKI) significantly contributes to morbidity and mortality in critically ill
patients. AKI is also an independent risk factor for the development and progression of …

Acute Kidney Injury (AKI), a critical clinical syndrome, has been strongly linked to
mitochondrial malfunction. Mitochondria, vital cellular organelles, play a key role in …