Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has
recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of …

Diabetes mellitus (DM) is a chronic metabolic disease characterized by the presence of
hyperglycemia, which can lead to many complications over time. These complications, such …

To analyse the effects of TGF-β in insulin dependent diabetes mellitus (IDDM), we have
developed non-obese diabetic (NOD) transgenic mice expressing TGF-β under the control …

The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell
types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon …

Type 2 diabetes is hallmarked by insulin resistance and insufficient β-cell function. Islets of
type 2 diabetes patients have been shown to have decreased hypoxia-inducible factor (HIF) …

Type 1 diabetes is inhibited in diabetes‐prone BioBreeding (BBdp) rats fed a low‐antigen
hydrolyzed casein (HC) diet. In cereal‐fed BBdp rats, islet expansion is defective …

Macrophages play a dynamic role in tissue repair following injury. Here we found that
following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages had …

Type II diabetes mellitus is associated with obesity and insulin resistance. However, many
humans with these symptoms never develop diabetes. This raises the key question of the …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …

Aims/hypothesis Type 2 diabetes is characterised by islet amyloid and toxic oligomers of
islet amyloid polypeptide (IAPP). We posed the questions,(1) does IAPP toxicity induce an …