OBJECTIVE Endothelial progenitor cells (EPCs) are decreased in number and function in
type 2 diabetes. Mechanisms by which this dysfunction occurs are largely unknown. We …

Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin,
blood, and gut, a stem cell reservoir has not been identified for some slower turnover …

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β
cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured …

Aims/hypothesis. As vascular endothelial growth factor (VEGF) plays a pivotal role in the
development of diabetic retinopathy, inhibition of angiogenesis induced by VEGF is crucial …

A better understanding of processes controlling the development and function of pancreatic
islets is critical for diabetes prevention and treatment. Here, we reveal a previously …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen with potent
angiogenic and vascular permeability-inducing properties, both of which may be important …

Substitution of pancreatic islets is a potential therapy to treat diabetes and it depends on
reconstitution of islet's capillary network. In this study, we addressed the question whether …

Vascular endothelial growth factor A (VEGF-A) is classically viewed as a key factor in
angiogenesis and tissue remodeling. However, recent evidence suggests a potential role of …

The prevalence of type 2 diabetes is rapidly increasing, with severe socioeconomic impacts,.
Excess lipid deposition in peripheral tissues impairs insulin sensitivity and glucose uptake …