Shared fine specificity between T-cell receptors and an antibody recognizing a peptide/major histocompatibility class I complex.
A Stryhn, PS Andersen, LO Pedersen… - Proceedings of the …, 1996 - National Acad Sciences
Cytotoxic T cells recognize mosaic structures consisting of target peptides embedded within
self-major histocompatibility complex (MHC) class I molecules. This structure has been …
self-major histocompatibility complex (MHC) class I molecules. This structure has been …
Molecular features of class II MHC-restricted T-cell recognition of protein and peptide antigens: the importance of amphipathic structures
Much work has been done on the use of peptides as immunogens, but most has
concentrated on antibody production (reviewed in L ERNER 1984; A RNON 1984) rather …
concentrated on antibody production (reviewed in L ERNER 1984; A RNON 1984) rather …
How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
T Mareeva, E Martinez-Hackert, Y Sykulev - Journal of biological chemistry, 2008 - ASBMB
We determined the crystal structures of the T cell receptor (TCR)-like antibody 25-D1. 16 Fab
fragment bound to a complex of SIINFEKL peptide from ovalbumin and the H-2K b molecule …
fragment bound to a complex of SIINFEKL peptide from ovalbumin and the H-2K b molecule …
Inhibition of allorecognition by an H-2Kb-derived peptide is evidence for a T-cell binding region on a major histocompatibility complex molecule.
J Schneck, T Munitz, JE Coligan… - Proceedings of the …, 1989 - National Acad Sciences
The class I and class II major histocompatibility complex (MHC) antigens are polymorphic
cell-surface glycoproteins that present antigenic peptides to T lymphocytes in the generation …
cell-surface glycoproteins that present antigenic peptides to T lymphocytes in the generation …
Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor
R Brock, KH Wiesmüller, G Jung… - Proceedings of the …, 1996 - National Acad Sciences
2C is a typical alloreactive cytotoxic T lymphocyte clone that recognizes two different
ligands. These ligands are adducts of the allo-major histocompatibility complex (MHC) …
ligands. These ligands are adducts of the allo-major histocompatibility complex (MHC) …
Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation
ACM Young, SG Nathenson… - The FASEB journal, 1995 - Wiley Online Library
The three‐dimensional structures of three human and two murine class I molecules, in
complex with single peptides and with mixtures of endogenous peptides, have now been …
complex with single peptides and with mixtures of endogenous peptides, have now been …
The interaction of antigenic peptides with the H-2Kd MHC class I molecule
JL Maryanski, R Lüthy, P Romero, F Healy… - Seminars in …, 1993 - Elsevier
An important event in the recognition of antigen by T cells is the selective interaction of
peptides with major histocompatibility complex (MHC) molecules. We have defined several …
peptides with major histocompatibility complex (MHC) molecules. We have defined several …
Topology and affinity of T-cell receptor mediated recognition of peptide—MHC complexes
MM Davis, Y Chien - Current opinion in immunology, 1993 - Elsevier
Significant progress has been made on several long-standing issues regarding T-cell
receptor mediated recognition of antigen-MHC complexes. For one, early data suggest that …
receptor mediated recognition of antigen-MHC complexes. For one, early data suggest that …
Alloreactive T cell recognition of MHC class I molecules: the T cell receptor interacts with limited regions of the MHC class I long alpha helices.
KD Smith, CT Lutz - Journal of immunology (Baltimore, Md.: 1950), 1997 - journals.aai.org
T cells recognize MHC-bound peptide, suggesting that the TCR contacts surface MHC
residues adjacent to bound peptide, but the extent of MHC contact is not known. T cells also …
residues adjacent to bound peptide, but the extent of MHC contact is not known. T cells also …
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides
AV Chervonsky, RM Medzhitov… - Proceedings of the …, 1998 - National Acad Sciences
Intracellular trafficking of major histocompatibility complex (MHC) class II molecules is
characterized by passage through specialized endocytic compartment (s) where antigenic …
characterized by passage through specialized endocytic compartment (s) where antigenic …