To examine the role of peptide in alloreactive class II MHC-restricted responses, we
transfected IA molecules into the Ag-processing defective mutant cell line, T2. Consistent …

Cytotoxic T lymphocyte (CTL) epitopes are naturally processed peptides bound and
presented by major histocompatibility (MHC) class I molecules. Since they are expressed at …

The understanding of chemically induced allergic or autoimmune disorders requires a
detailed structural analysis of the antigenic determinants produced by chemical modification …

Mature T lymphocytes are activated by recognition of the combination of foreign protein
antigen and membrane products of the major histocompatibility complex (MHC) 1. Studies of …

TCR engagement of peptide-MHC class II ligands involves specific contacts between the
TCR and residues on both the MHC and peptide molecules. We have used molecular …

Recognition by a T-cell antigen receptor (TCP) of peptide complexed with a major histo-
compatibility complex (MHC) molecule occurs through variable loops in the TCP structure …

The binding of antigenic peptide to class II MHC is mediated by hydrogen bonds between
the MHC and the peptide, by salt bridges, and by hydrophobic interactions. The latter are …

Specificity in the immune system is dictated and regulated by specific recognition of
peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such …

We have examined the interactions of various peptides with the mouse class II major
histocompatibility complex molecule I-Ak. The peptides were derived from the model protein …

Molecular mimicry, normally defined by the level of primary-sequence similarities between
self and foreign antigens, has been considered a key element in the pathogenesis of …