[HTML][HTML] Glycogen synthase kinase-3 signaling in Alzheimer's disease

E Lauretti, O Dincer, D Praticò - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …

Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors

J Avila, F Wandosell, F Hernández - Expert Review of …, 2010 - Taylor & Francis
Glycogen synthase kinase (GSK)-3 has been proposed as the link between the two
histopathological hallmarks of Alzheimer's disease, the extracellular senile plaques …

[HTML][HTML] GSK-3 and Tau: a key duet in Alzheimer's disease

CL Sayas, J Ávila - Cells, 2021 - mdpi.com
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …

Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease

HC Huang, PS Klein - Current drug targets, 2006 - ingentaconnect.com
Alzheimer's disease (AD) is a common neurodegenerative disorder that presents clinically
as inexorable cognitive impairment and decline in performance of activities of daily living …

[HTML][HTML] GSK-3β, a pivotal kinase in Alzheimer disease

M Llorens-Marítin, J Jurado, F Hernández… - Frontiers in molecular …, 2014 - frontiersin.org
Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …

The GSK3 hypothesis of Alzheimer's disease

C Hooper, R Killick, S Lovestone - Journal of neurochemistry, 2008 - Wiley Online Library
J. Neurochem.(2008) 104, 1433–1439. Abstract Glycogen synthase kinase 3 (GSK3) is a
constitutively active, proline‐directed serine/threonine kinase that plays a part in a number of …

GSK3β signalling: casting a wide net in Alzheimer's disease

RV Bhat, SL Budd - Neurosignals, 2002 - karger.com
Glycogen synthase kinase-3β (GSK3β) is a kinase that plays a pivotal role in numerous
cellular functions from modulation of microtubule dynamics and cell death. It also affects …

Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease

M Medina, J Avila - Current pharmaceutical design, 2010 - ingentaconnect.com
Originally discovered because of its role in the regulation of glucose metabolism, Glycogen
Synthase Kinase-3 (GSK-3) is now recognised as a crucial player in a diverse series of …

[HTML][HTML] Modulation of GSK-3 as a therapeutic strategy on tau pathologies

M Medina, JJ Garrido, FG Wandosell - Frontiers in molecular …, 2011 - frontiersin.org
Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed and unusually active in
resting, non-stimulated cells. In mammals, at least three proteins (α, β1, and β2), generated …

[HTML][HTML] The role of glycogen synthase kinase 3 beta in neurodegenerative diseases

H Yu, M Xiong, Z Zhang - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDDs) pose an increasingly prevalent threat to the well-being
and survival of elderly individuals worldwide. NDDs include Alzheimer's disease (AD) …