Because of the presence of the blood–brain barrier, brain renin–angiotensin system activity
should depend on local (pro) renin synthesis. Indeed, an intracellular form of renin has been …

The existence of a so-called brain renin-angiotensin system (RAS) is controversial. Given
the presence of the blood–brain barrier, angiotensin generation in the brain, if occurring …

The brain renin–angiotensin system is implicated in the regulation of blood pressure (BP)
and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain …

The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure,
but the mechanisms regulating RAS activity in the brain remain unclear. Expression of brain …

Renin plays a key role in controlling blood pressure through its specific cleavage of
angiotensinogen to generate angiotensin I (AI). Although possible existence of the other …

1008 Hypertension June 2017 renin, angiotensin-converting enzyme, and the angiotensin
type 1 receptor in the brain. Thus, these data, which did not involve any exogenous …

The renin–angiotensin system (RAS) plays a central role in the brain to regulate blood
pressure (BP). This role includes the modulation of sympathetic nerve activity (SNA) that …

The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and
developmental regulation, is present in both the circulation and in many individual tissues …

The brain-specific isoform of renin (Ren-b) has been proposed as a negative regulator of the
brain renin–angiotensin system (RAS). We analyzed mice with a selective deletion of Ren-b …

All components of the renin-angiotensin system are localized in the brain. However,
because renin is present in very low concentrations, the mechanism by which angiotensin II …