An indispensable role for the brain renin-angiotensin system (RAS) has been documented
in most experimental animal models of hypertension. To identify the specific efferent …

Since the first description of renin, angiotensinogen and angiotensin as well as converting
enzyme and angiotensin receptors in the brain exactly 30 years ago, 1–5 there was a …

Nakagawa and Sigmund Regulation of the Brain RAS 11 processing proteases including
tonin and cathepsin G with a broad spectrum of substrate affinities. 27 Ang-(1–12), a peptide …

Rationale: Despite overwhelming evidence of the importance of brain renin–angiotensin
system (RAS), the very existence of intrinsic brain RAS remains controversial. Objective: To …

Objective: To evaluate the significance of locally synthesized renin in the pathogensis of
hypertension, we investigated modulation of the renin gene expression in extrarenal tissues …

It is well known that the brain renin‐angiotensin (RAS) system plays an essential role in the
development of hypertension, mainly through the modulation of autonomic activities and …

We previously reported the generation of 2 novel transgenic mouse models containing the
human renin (hREN) gene encoded on P1 artificial chromosomes (PAC) containing large …

Hypertension remains one of the largest human health problems, because hypertensive
patients carry increased risk for ischemic heart disease, stroke, atherosclerosis, and renal …

The (pro) renin receptor (PRR), which binds both renin and prorenin, is a newly discovered
component of the renin–angiotensin system that is highly expressed in the central nervous …

The (pro) renin receptor is a newly discovered member of the brain renin-angiotensin
system. To investigate the role of brain (pro) renin receptor in hypertension, adeno …