When Saccharomyces cerevisiae grows on mixtures of glucose and galactose, galactose
utilization is repressed by glucose, and induction of the GAL gene network only occurs when …

Glucose repression is a central regulatory system in yeast that ensures the utilization of
carbon sources in a highly economical manner. The galactose (GAL) metabolism network is …

Increasing the flux through central carbon metabolism is difficult because of rigidity in
regulatory structures, at both the genetic and the enzymatic levels. Here we describe …

The evolution of novel traits can involve many mutations scattered throughout the genome,.
Detecting and validating such a suite of alleles, particularly if they arose long ago, remains a …

Galactose is a secondary fermentable sugar that requires specific regulatory and structural
genes for its assimilation, which are under catabolite repression by glucose. When glucose …

The Leloir galactose utilization or GAL pathway of budding yeasts, including that of the
baker's yeast Saccharomyces cerevisiae and the opportunistic human pathogen Candida …

Understanding the genetic basis of evolutionary adaptation is limited by our ability to
efficiently identify the genomic locations of adaptive mutations. Here we describe a method …

Despite their close phylogenetic relationship, Kluyveromyces lactis and Saccharomyces
cerevisiae have adapted their carbon utilization systems to different environments. Although …

Understanding the evolutionary relationship between genome content and ecological niche
is one of the fundamental challenges of biology. The distinct physiologies of yeast species …

Identification of the underlying molecular mechanisms for a derived phenotype by adaptive
evolution is difficult. Here, we performed a systems-level inquiry into the metabolic changes …