[HTML][HTML] Estrogen receptors and their implications in colorectal carcinogenesis
Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …
intracellular signaling cascades that have important consequences for cellular behavior …
Targeting estrogen receptors in colorectal cancer
JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …
them to optimize the health benefits and avoid adverse effects is a major challenge …
Molecular pathways: estrogen pathway in colorectal cancer
A Barzi, AM Lenz, MJ Labonte, HJ Lenz - Clinical cancer research, 2013 - AACR
Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …
a protective role for sex hormones in the development of the disease. Preclinical data …
Implications of estrogen and its receptors in colorectal carcinoma
Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …
Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells
K Edvardsson, A Ström, P Jonsson… - Molecular …, 2011 - academic.oup.com
Several studies suggest estrogen to be protective against the development of colon cancer.
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …
[HTML][HTML] Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
L Hases, R Indukuri, M Birgersson, T Nguyen-Vu… - Cancer letters, 2020 - Elsevier
Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of
estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals …
estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals …
Estrogen receptor beta as target for colorectal cancer prevention
Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …
development and the capacity for early diagnosis, current preventive approaches are not …
[HTML][HTML] ERβ is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components
V Martineti, L Picariello, I Tognarini… - Endocrine-related …, 2005 - erc.bioscientifica.com
Several strands of evidence indicate that oestrogens exert a protective role against the
development of colon cancer through indirect and direct effects on colonic epithelium …
development of colon cancer through indirect and direct effects on colonic epithelium …
[HTML][HTML] Estrogen signaling via estrogen receptor β
C Zhao, K Dahlman-Wright, JÅ Gustafsson - Journal of Biological Chemistry, 2010 - ASBMB
Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ.
Transcriptional regulation by ERs is controlled by a complex array of factors such as ER …
Transcriptional regulation by ERs is controlled by a complex array of factors such as ER …
Oestrogen and the colon: potential mechanisms for cancer prevention
R Kennelly, DO Kavanagh, AM Hogan… - The lancet oncology, 2008 - thelancet.com
The role of oestrogen in oncogenesis has been examined extensively, especially in the
context of breast cancer, and receptor modulators are an integral part of targeted treatment …
context of breast cancer, and receptor modulators are an integral part of targeted treatment …