Colon cancer is a common cause of cancer death in the Western world. Accumulating
evidence supports a protective role of estrogen via estrogen receptor beta (ERβ) but the …

While it is well documented that the mitogenic actions of estrogens are critical in the
development and progression of human breast and some gynecologic cancers, only latest …

Obesity is associated with the increased incidence of colon cancer. Many cancer risk factors
have been identified including increased blood levels of insulin, leptin, interleukin-6 …

Two different isoforms of the estrogen receptors (ie, ERα and ERβ) mediate pleiotropic 17β-
estradiol (E2)-induced cellular effects. The ERs are principally localized in the nucleus …

By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ
exert opposite effects on cellular processes that include proliferation, apoptosis and …

Colon cancer is the most frequent neoplasia of the intestine. This pathology is the third
highest cause of death from cancer with 430,000 deaths globally per year. Estrogen has …

Estrogens play a fundamental role in the development and normal physiological function of
multiple tissue systems and have been implicated in the ontogeny of cancers. The biological …

Estrogen replacement therapy in postmenopausal women is associated with a reduction in
colorectal cancer risk, potentially via interactions between 17β-estradiol (E2) and the …

Estrogen exhibits a broad spectrum of physiological functions ranging from regulation of the
menstrual cycle and reproduction to modulation of bone density, brain function, and …

Although estrogen receptors (ERs) are expressed in human hepatocellular carcinoma
(HCC), several clinical trials have failed to demonstrate the efficacy of antiestrogen treatment …