The involvement of estrogen and its receptors in the development of cancer has been known
for years. However, the exact mechanism responsible is far from clear. The estrogen …

Abstract 17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many
tissue and organ functions in physiology. The effects of E2 on cells are mediated by the …

Together with the estrogen receptor (ER) alpha, estrogen receptor beta (ERβ) mediates
many of the physiological effects of estrogens. As ERβ is crucially involved in a variety of …

Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of
nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize …

Aim The role of oestrogen metabolism and action in colorectal cancer (CRC) is
controversial. An extensive review of the current literature, encompassing epidemiological …

The biological actions of estrogens are mediated by estrogen binding to one of two specific
estrogen receptors (ERs) ERα and ERβ, which belong to the nuclear receptor superfamily, a …

The temporal and tissue-specific actions of estrogen are mediated by estrogen receptors α
and β. The ERs are steroid hormone receptors that modulate the transcription of target …

Menopausal hormone replacement therapy has been widely used to alleviate the symptoms
of menopause and to decrease the detrimental effects of ovarian hormone loss on bone …

Estrogen receptors (ERs) mediate the effects of 17β-estradiol under physiologic and
pathologic conditions. ERs trigger 17β-estradiol-sensitive gene transcription by binding to …

Evidence exists for expression of estrogen receptor β (ERβ) in human colonic mucosa. Here
we investigated the expression of the classical ER (ERα) and of four isoforms of the human …