[HTML][HTML] The impact of obesity, adipose tissue, and tumor microenvironment on macrophage polarization and metastasis

O Habanjar, M Diab-Assaf, F Caldefie-Chezet, L Delort - Biology, 2022 - mdpi.com
Simple Summary The inflammatory adipose microenvironment in obesity plays a crucial role
in cancer development and metastases. By focusing on adipocytes and macrophages, as …

[HTML][HTML] Adipocytes and macrophages interplay in the orchestration of tumor microenvironment: new implications in cancer progression

LH Corrêa, R Corrêa, CM Farinasso… - Frontiers in …, 2017 - frontiersin.org
Inflammation has been known as one of the main keys to the establishment and progression
of cancers. Chronic low-grade inflammation is also a strategic condition that underlies the …

Adipose tissue macrophages: the inflammatory link between obesity and cancer?

M Wagner, ES Samdal Steinskog… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Obesity has increased dramatically over the last three decades. Thus,
epidemiological evidence linking obesity and cancer has ignited our interest in the …

[HTML][HTML] The adipocyte–macrophage relationship in cancer: A potential target for antioxidant therapy

S Sanhueza, L Simón, M Cifuentes, AFG Quest - Antioxidants, 2023 - mdpi.com
Obesity has emerged as a major public health concern with a staggering 39% worldwide
prevalence as of 2021. Given the magnitude of the problem and considering its association …

[HTML][HTML] Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism

M Lee-Rueckert, M Canyelles, M Tondo… - Seminars in cancer …, 2023 - Elsevier
Obesity has been closely related to cancer progression, recurrence, metastasis, and
treatment resistance. We aim to review recent progress in the knowledge on the obese …

Cancer as a matter of fat: the crosstalk between adipose tissue and tumors

E Lengyel, L Makowski, J DiGiovanni, MG Kolonin - Trends in cancer, 2018 - cell.com
Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Obesity programs macrophages to support cancer progression

A Singh, SS Mayengbam, H Yaduvanshi, MR Wani… - Cancer research, 2022 - AACR
Obesity induces multifactorial effects such as dyslipidemia, insulin resistance, and arterial
hypertension that influence the progression of many diseases. Obesity is associated with an …

Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression

CA Gilbert, JM Slingerland - Annual review of medicine, 2013 - annualreviews.org
Obesity is a problem of epidemic proportions in many developed nations. Increased body
mass index and obesity are associated with a significantly worse outcome for many cancers …

[HTML][HTML] The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

MN Duong, A Geneste, F Fallone, X Li, C Dumontet… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Growing evidence has raised the important roles of adipocytes as an active player in the
tumor microenvironment. In many tumors adipocytes are in close contact with cancer cells …

Emerging concepts linking obesity with the hallmarks of cancer

CL Donohoe, J Lysaght, J O'Sullivan… - Trends in Endocrinology & …, 2017 - cell.com
There is compelling epidemiological evidence linking obesity to many tumours; however, the
molecular mechanisms fuelling this association are not clearly understood. Emerging …