Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils

S Loffredo, F Borriello, R Iannone, AL Ferrara… - Frontiers in …, 2017 - frontiersin.org
Secreted phospholipases A2 (sPLA2s) are extracellular enzymes that catalyze the release
of free fatty acids and lysophospholipids from membrane phospholipids and also bind to …

Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis

J Kreuger, M Phillipson - Nature Reviews Drug Discovery, 2016 - nature.com
Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and
angiogenesis are all processes that occur at the level of the microvasculature during both …

Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D

KW Tan, SZ Chong, FHS Wong… - Blood, The Journal …, 2013 - ashpublications.org
Lymphangiogenesis is an important physiological response to inflammatory insult, acting to
limit inflammation. Macrophages, dendritic cells, and lymphocytes are known to drive …

[HTML][HTML] Fibroblast activation in vascular inflammation

A Enzerink, A Vaheri - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Vascular inflammation is implicated in both local and systemic inflammatory conditions.
Endothelial activation and leukocyte extravasation are key events in vascular inflammation …

Emerging mechanisms of neutrophil recruitment across endothelium

MR Williams, V Azcutia, G Newton, P Alcaide… - Trends in …, 2011 - cell.com
Neutrophils are the all-terrain vehicle of the innate immune system because of their ability to
gain entry into tissues and organs, and thus, play an essential role in host defense. Exactly …

The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes

V Tchaikovski, G Fellbrich… - … thrombosis, and vascular …, 2008 - Am Heart Assoc
Objective—Arteriogenesis, the growth of preexisting arterioles into functional arteries, is
dependent on the proper function of monocytes. Likewise, wound healing is monocyte …

Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner

S Ahmad, MJ Cudmore, K Wang, P Hewett, R Potluri… - …, 2010 - Am Heart Assoc
Angiopoietin-1 (Ang-1) is an angiogenic growth factor that activates Tie-2 and integrins to
promote vessel wall remodeling. The recent finding of the potential proatherogenic effects of …

PGF2α, a prostanoid released by endothelial cells activated by hypoxia, is a chemoattractant candidate for neutrophil recruitment

T Arnould, R Thibaut-Vercruyssen, N Bouaziz… - The American journal of …, 2001 - Elsevier
Despite increasing evidence supporting the involvement of neutrophils in ischemic and
postischemic damages, the mechanisms underlying the early recruitment of these cells are …

Interleukin‐1α (IL‐1α) promotes angiogenesis in vivo via VEGFR‐2 pathway by inducing inflammatory cell VEGF synthesis and secretion

P Salven, K Hattori, B Heissig, S Rafii - The FASEB Journal, 2002 - Wiley Online Library
During inflammation, functional changes occur in the vasculature, including extensive
endothelial cell mitotic activity and remodeling of capillaries. Interleukin‐1α.(IL‐1α) is a …

Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation

P Dentelli, LD Sorbo, A Rosso, A Molinar… - The Journal of …, 1999 - journals.aai.org
Angiogenesis is a critical process for growth of new capillary blood vessels from preexisting
capillaries and postcapillary venules, both in physiological and pathological conditions …