Shotgun proteomics dominates the field of proteomics. The foundations of the strategy
consist of multiple rounds of peptide separation where chromatography provides the …

Sample complexity and dynamic range constitute enormous challenges in proteome
analysis. The back-end technology in typical proteomics platforms, namely mass …

Multidimensional liquid-based separation techniques are described for maximizing the
resolution of the enormous number of peptides generated upon tryptic digestion of …

Current solution based proteomic analysis methods are generally based on enzymatic
digestion of a protein mixture followed by separation using multidimensional liquid …

Large-scale proteomics often employs two orthogonal separation methods to fractionate
complex peptide mixtures. Fractionation can involve ion exchange separation coupled to …

Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …

Proteomics is the study of all or part of the protein complement of genes in an organism,
often involving the analysis of complex protein/peptide samples. Such complex samples are …

Proteomics, the characterization of the proteome, is conceptually simple but technically
challenging. Development of such technologies as mass spectrometry, multidimensional …

Proteome was first coined by describing the set of proteins encoded by the genome, and the
study of proteome, named as proteomics, aims at globally characterizing all components in a …

The complexity of the human serum proteome is attributed to both a large dynamic range of
protein abundance, as much as 10 orders of magnitude, and a disproportionate few dozens …