Compromised cellular energy metabolism, cerebral hypoperfusion, and neuronal calcium
dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP …

In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (K
ATP) are involved in neural function and plasticity. Moreover, alterations in K ATP activity …

Pharmacological modulation of ATP-sensitive potassium channels has become a promising
new therapeutic approach for the treatment of neurodegenerative diseases due to their role …

Oxygen-sensing and responses to changes in oxygen concentration is a fundamental
property of cellular physiology. In the central nervous system (CNS), hippocampal CA1 …

ATP-sensitive potassium channels (K ATP channels), a group of vital channels that link the
electrical activity of the cell membrane with cell metabolism, were discovered on the …

Affective disorders including depression and anxiety are among the most prevalent
behavioral abnormalities in patients with Alzheimer's disease (AD), which affect the quality …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-
amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Recent …

Diazoxide (DZ), a highly selective opener of the mitochondrial ATP-sensitive potassium
(mitoK ATP) channel, has neuroprotective effects against neuronal cell death by reducing …

Abstract Background The pathology of Alzheimer's disease (AD) is comprised of
extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and …

Aims Several studies suggested that ATP-sensitive potassium channels (K ATP) are
potential therapeutic targets for protection against various neurodegenerative disorders, yet …