Antibiotic resistance is an emerging global medical crisis. Resistant pathogens can evolve
and spread rapidly in response to selection pressures exerted by antibiotics. A major …

Bacterial recombination is believed to be a major factor explaining the prevalence of multi-
drug-resistance (MDR) among pathogenic bacteria. Despite extensive evidence for …

Antibiotic combinations are considered a relevant strategy to tackle the global antibiotic
resistance crisis since they are believed to increase treatment efficacy and reduce …

Antibiotic combinations are considered a relevant strategy to tackle the global antibiotic
resistance crisis since they are believed to increase treatment efficacy and reduce …

Alternating antibiotic therapy, in which pairs of drugs are cycled during treatment, has been
suggested as a means to inhibit the evolution of de novo resistance while avoiding the …

Multidrug regimes have been considered to constrain selection for resistance compared to
monotherapy. However, drug resistance trajectories are influenced by a wide range of …

Antibiotic resistance is a global threat to human health, wherefore it is crucial to study the
mechanisms of antibiotic resistance as well as its emergence and dissemination. One way to …

Antibiotic combination therapies are an approach used to counter the evolution of
resistance; their purported benefit is they can stop the successive emergence of …

In combination therapy, bacteria are challenged with two or more antibiotics simultaneously.
Ideally, separate mutations are required to adapt to each of them, which is a priori expected …

The emergence of drug resistant pathogens is a serious public health problem. It is a long-
standing goal to predict rates of resistance evolution and design optimal treatment strategies …