Emulating a target trial to assess effect modification: an application to obesity in the comparative effectiveness and safety of apixaban versus warfarin in non-valvular …

TM Bin Hammad, E Powell, PJ Baptiste, I Douglas… - medRxiv, 2023 - medrxiv.org
Anticoagulation therapy is recommended for patients with non-valvular atrial fibrillation
(NVAF) and an increased risk of stroke. Although apixaban showed superiority over warfarin …

Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with …

A González-Pérez, L Roberts, P Vora, ME Saez… - BMJ open, 2022 - bmjopen.bmj.com
Objectives To investigate effects of appropriately and inappropriately dosed
apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with …

Efficacy and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation across BMI categories: a systematic review and meta-analysis

Y Zhou, J Ma, W Zhu - American Journal of Cardiovascular Drugs, 2020 - Springer
Objectives Concerns have arisen recently over the relationship between body mass index
(BMI) and outcomes in atrial fibrillation (AF) patients with direct oral anticoagulants (DOACs) …

Comparative effectiveness and safety of rivaroxaban in adults with nonvalvular atrial fibrillation

WS Aronow, TA Shamliyan - American Journal of Therapeutics, 2019 - journals.lww.com
Background: All evidence regarding benefits and harms of rivaroxaban for stroke prevention
has not been appraised yet. Study Question: What are the comparative effectiveness and …

Effectiveness and safety of standard-and low-dose rivaroxaban in Asians with atrial fibrillation

YC Lin, SC Chien, YC Hsieh, CM Shih, FY Lin… - Journal of the American …, 2018 - jacc.org
Abstract Background: Low-dose rivaroxaban (10 mg/day) has been widely used in Asia for
patients with atrial fibrillation (AF), although there is a lack of evidence regarding its …

Association of rivaroxaban vs apixaban with major ischemic or hemorrhagic events in patients with atrial fibrillation

WA Ray, CP Chung, CM Stein, W Smalley… - Jama, 2021 - jamanetwork.com
Importance The comparative effectiveness of rivaroxaban and apixaban, the most frequently
prescribed oral anticoagulants for ischemic stroke prevention in patients with atrial …

Effectiveness and safety of low-dose versus standard-dose rivaroxaban and apixaban in patients with atrial fibrillation

S Perreault, R Cote, A Dragomir, B White-Guay… - Plos one, 2022 - journals.plos.org
Background Low-dose direct oral anticoagulant (DOAC) use is quite prevalent in clinical
practice, but evidence of its effectiveness and safety compared with high-dose DOAC in …

Safety and efficacy of direct oral anticoagulants in comparison to warfarin in obese patients with atrial fibrillation: A systematic review and meta‐analysis

A Adelkhanova, PR Oli, DB Shrestha… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aim Obesity affects nearly 650 million adults worldwide, and the
prevalence is steadily rising. This condition has significant adverse effects on cardiovascular …

Adverse events in low versus normal body weight patients prescribed apixaban for atrial fibrillation

D DeCamillo, B Haymart, X Kong, S Kaatz… - Journal of thrombosis …, 2023 - Springer
Safety and efficacy of direct oral anticoagulants (DOAC) in low weight patients with atrial
fibrillation (AF) is unclear due to few low body weight patients enrolled in clinical trials. To …

Association between body mass index and clinical outcomes in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants: a new piece of …

S Wu, N Huang, X Chen, S Jiang, W Zhang… - … Drugs and Therapy, 2023 - Springer
Purpose We conducted a multicenter real-world study in China to assess the association
between body mass index (BMI) and clinical outcomes in patients with atrial fibrillation (AF) …