The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - Annals of surgical …, 2007 - Springer
Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …
hypoxic microenvironment plays a crucial role in malignant progression. We previously …
Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathway
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - … journal of cancer, 2006 - Wiley Online Library
The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …
progression. The interaction between stromal and cancer cells also contributes to the …
Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c‐Met system via hypoxia inducible factor‐1 in …
Y Kitajima, T Ide, T Ohtsuka, K Miyazaki - Cancer science, 2008 - Wiley Online Library
Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …
Hypoxia induces immunosuppression, metastasis and drug resistance in pancreatic cancers
H Zhang, K Cao, J Xiang, M Zhang, M Zhu, Q Xi - Cancer Letters, 2023 - Elsevier
Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential
AV Salnikov, L Liu, M Platen, J Gladkich, O Salnikova… - 2012 - journals.plos.org
Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …
and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de …
[HTML][HTML] HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic …
T Katagiri, M Kobayashi, M Yoshimura, A Morinibu… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Hypoxic and stroma-rich microenvironments, characteristic features of pancreatic cancers,
are strongly associated with a poor prognosis. However, whether and how hypoxia …
are strongly associated with a poor prognosis. However, whether and how hypoxia …
The impact of hypoxia in pancreatic cancer invasion and metastasis
A Yuen, B Díaz - Hypoxia, 2014 - Taylor & Francis
Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …
Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition
Background Epidermal growth factor receptor (EGFR) is an essential target for cancer
treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic …
treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic …
Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
O Hashimoto, K Shimizu, S Semba, S Chiba, Y Ku… - Pathobiology, 2011 - karger.com
Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …
Dominant-negative hypoxia-inducible factor-1α reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …