Determination of heroin and its main metabolites in small sample volumes of whole blood and brain tissue by reversed-phase liquid chromatography-tandem mass …

R Karinen, JM Andersen, Å Ripel… - Journal of analytical …, 2009 - academic.oup.com
A high-performance liquid chromatography-tandem mass spectrometry (LC-MS-MS) method
has been developed for the quantitative analysis of heroin and its major metabolites 6 …

Simultaneous determination of heroin, 6-monoacetylmorphine, morphine, and its glucuronides by liquid chromatography-atmospheric pressure ionspray-mass …

P Zuccaro, R Ricciarello, S Pichini… - Journal of analytical …, 1997 - academic.oup.com
A new analytical technique has been developed for the simultaneous determination of
heroin, 6-monoacetylmorphine, morphine, morphine-6-and 3-glucuronides, and codeine in …

High-performance liquid chromatography-mass spectrometry-mass spectrometry analysis of morphine and morphine metabolites and its application to a …

M Zheng, KM McErlane, MC Ong - Journal of Pharmaceutical and …, 1998 - Elsevier
A high-performance liquid chromatography tandem mass spectrometry-mass spectrometry
(LC-MS-MS) assay was developed for the analyses of morphine, morphine glucuronides …

Development and validation of a reliable method for studying the distribution pattern for opiates metabolites in brain

K Guerrini, A Argo, C Borroni, D Catalano… - … of pharmaceutical and …, 2013 - Elsevier
Brain distribution pattern of “street” heroin metabolites (morphine and codeine) was
investigated in two fatalities due to “acute narcotism”. A suitable sample pretreatment prior to …

Morphine, morphine-3-glucuronide, morphine-6-glucuronide, and 6-monoacetylmorphine determined by means of atmospheric pressure chemical ionization-mass …

MJ Bogusz, RD Maier, S Driessen - Journal of Analytical …, 1997 - academic.oup.com
Abstract Morphine, morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), and 6-
monoacetylmorphine (6-MAM) were isolated from body fluids using solid-phase extraction …

Simultaneous measurement of heroin and its metabolites in brain extracellular fluid by microdialysis and ultra performance liquid chromatography tandem mass …

A Gottas, EL Oiestad, F Boix, A Ripel… - … of pharmacological and …, 2012 - Elsevier
INTRODUCTION: The pharmacokinetic profile and systemic bioavailability of a substance is
often described by blood or total tissue concentrations. For centrally acting drugs, like …

Rapid, highly sensitive method for the determination of morphine and its metabolites in body fluids by liquid chromatography–mass spectrometry

G Schänzle, S Li, G Mikus, U Hofmann - Journal of Chromatography B …, 1999 - Elsevier
A rapid, highly sensitive method for the determination of morphine and its metabolites
morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and normorphine has been …

Rapid and simple method to determine morphine and its metabolites in rat plasma by liquid chromatography–mass spectrometry

D Projean, TM Tu, J Ducharme - Journal of Chromatography B, 2003 - Elsevier
A rapid and simple method for the determination of morphine (M), normorphine (NM),
morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) in plasma by high …

GLC determination of heroin and its metabolites in human urine

SY Yeh, RL McQuinn - Journal of Pharmaceutical Sciences, 1975 - Elsevier
Heroin and its metabolites, 6‐monoacetylmorphine, morphine, and normorphine, were
determined in human urine with a GLC procedure. Heroin was extracted with chloroform at …

The role of liquid chromatography–mass spectrometry in the determination of heroin and related opioids in biological fluids

S Pichini, I Altieri, M Pellegrini… - Mass Spectrometry …, 1999 - Wiley Online Library
The opioid most commonly sold in the illicit market is heroin. This substance, classified as an
analgesic narcotic drug, has an extremely short half‐life, and it is rapidly metabolized to 6 …