The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most
organisms. Nedd8/RUB has been shown to modify the cullin subunit of culling-based …

The ubiquitin-like protein Nedd8/Rub1 covalently modifies and activates cullin ubiquitin
ligases. However, the repertoire of Nedd8-modified proteins and the regulation of protein …

The importance of the ubiquitin system largely depends on ubiquitin ligases, E3s, as they
determine the specificity of the system. Rbx1/ROC1/Hrt1, a RING finger protein, functions as …

Cullin-based E3 ligases are a large family of multi-subunit ubiquitin ligases with diverse
cellular functions, including the regulation of the cell cycle, of the DNA damage response …

Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other
proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets …

Covalent modification of cullins by the ubiquitin-like protein NEDD8 (neddylation) regulates
protein ubiquitination by promoting the assembly of cullin-RING ligase E3 complexes. Like …

Nedd4 is a member of a growing family of ubiquitin-protein ligases which consist of a lipid-
binding domain, two to four WW domains and a C-terminal ubiquitin-protein ligase domain …

Abstract Skp1‐Cdc53/Cul1‐F‐box (SCF) complexes constitute a class of E3 ubiquitin
ligases. Recently, a multiprotein complex containing pVHL, elongin C and Cul2 (VEC) was …

NEDD8/Rub1 is a ubiquitin (Ub)-like molecule that covalently ligates to target proteins
through an enzymatic cascade analogous to ubiquitylation. This modifier is known to target …

The Cullin-RING ubiquitin ligase (CRL) family, which may number as many as 350 different
enzymes, has an enormous impact on cellular regulation. CRL enzymes regulate cell …