STING (stimulator of interferon genes) is a cytosolic sensor for cyclic dinucleotides and also
an adaptor molecule for intracellular DNA receptors. Although STING has important …

Detection of cytoplasmic DNA by the host's innate immune system is essential for microbial
and endogenous pathogen recognition. In mammalian cells, an important sensor is the …

The gastrointestinal tract is a highly complex microenvironment under constant interaction
with potentially harmful pathogens. Inflammatory bowel disease (IBD) is an archetypical …

Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic
dinucleotides that also serves a dual role as an adaptor molecule for a number of …

Alterations in the cGAS-STING DNA-sensing pathway affect intestinal homeostasis. We
sought to delineate the functional role of STING in intestinal inflammation. Increased STING …

Background Gut integrity is compromised in abdominal sepsis with increased cellular
apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a …

Abstract Background Intestinal Immunoglobulin A (IgA) is crucial in maintaining host-
microbiota mutualism and gut homeostasis. It has been shown that many species of gut …

Extensive studies demonstrate the importance of the STING1 (also known as STING) protein
as a signaling hub that coordinates immune and autophagic responses to ectopic DNA in …

Intestinal immune homeostasis is preserved by commensal bacteria interacting with the host
to generate a balanced array of cytokines that are essential for wound repair and for …

Generation of protective immune responses requires coordinated stimulation of innate and
adaptive immune responses. An important mediator of innate immunity is stimulator of IFN …