Background T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic,
inflammatory, demyelinating disease of the central nervous system (CNS). Although several …

In this study we characterized the TCR repertoire profiles in patients with chronic
progressive inflammatory neurological disorders including HAM/TSP, associated with …

The importance of T‐cell receptor (TCR) repertoire diversity is highlighted in murine models
of immunodeficiency and in many human pathologies. However, the true extent of TCR …

Multiple sclerosis is an inflammatory demyelinating disease of the CNS associated with T
cells autoreactive for myelin components. In this study, we analysed the T‐cell receptor …

Natalizumab (NTZ) and autologous hematopoietic stem cell transplantation (AHSCT) are
two successful treatments for relapsing-remitting multiple sclerosis (RRMS), an autoimmune …

The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …

Objective To characterize T‐cell receptors (TCRs) and identify target epitopes in multiple
sclerosis (MS). Methods Peripheral blood mononuclear cells were obtained from 39 MS …

Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

Background Several lines of evidence suggest that transcription factors are involved in the
pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has …

T cells and B cells are crucial in the initiation and maintenance of multiple sclerosis (MS),
and the activation of these cells is believed to be mediated through specific recognition of …