Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy
The ability to self-assemble one-dimensional DNA building blocks into two-and three-
dimensional nanostructures via DNA/RNA nanotechnology has led to broad applications in …
dimensional nanostructures via DNA/RNA nanotechnology has led to broad applications in …
Aptamers as diagnostic tools in cancer
D Ruiz Ciancio, MR Vargas, WH Thiel, MA Bruno… - Pharmaceuticals, 2018 - mdpi.com
Cancer is the second leading cause of death worldwide. Researchers have been working
hard on investigating not only improved therapeutics but also on early detection methods …
hard on investigating not only improved therapeutics but also on early detection methods …
Nanomaterial based aptasensors for clinical and environmental diagnostic applications
Nanomaterials have been exploited extensively to fabricate various biosensors for clinical
diagnostics and food & environmental monitoring. These materials in conjugation with highly …
diagnostics and food & environmental monitoring. These materials in conjugation with highly …
Structure-switching aptamer triggering hybridization chain reaction on the cell surface for activatable theranostics
YM Wang, Z Wu, SJ Liu, X Chu - Analytical chemistry, 2015 - ACS Publications
The ability to probe low-abundance biomolecules or transport a high-load drug in target
cells is essential for biology and theranostics. We develop a novel activatable theranostic …
cells is essential for biology and theranostics. We develop a novel activatable theranostic …
Aptamers: multifunctional molecules for biomedical research
J Banerjee, M Nilsen-Hamilton - Journal of molecular medicine, 2013 - Springer
Aptamers are single-stranded oligonucleotides that fold into well-defined three-dimensional
shapes, allowing them to bind their targets with high affinity and specificity. They can be …
shapes, allowing them to bind their targets with high affinity and specificity. They can be …
Aptamer-conjugated optical nanomaterials for bioanalysis
Q Yuan, D Lu, X Zhang, Z Chen, W Tan - TRAC Trends in Analytical …, 2012 - Elsevier
We review advances in the development and the application of optical biosensing systems
based on aptamers. Aptamers exhibit advantages as molecular recognition elements for …
based on aptamers. Aptamers exhibit advantages as molecular recognition elements for …
Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy
HM Meng, T Fu, XB Zhang, W Tan - National Science Review, 2015 - academic.oup.com
Nucleic acid aptamers, which are generated by a novel technique called SELEX (systematic
evolution of ligands by exponential enrichment), have recently attracted significant attention …
evolution of ligands by exponential enrichment), have recently attracted significant attention …
Applications of cancer cell-specific aptamers in targeted delivery of anticancer therapeutic agents
Aptamers are single-stranded oligonucleotides that specifically bind and interact with their
corresponding targets, including proteins and cells, through unique three-dimensional …
corresponding targets, including proteins and cells, through unique three-dimensional …
DNA aptamer technology for personalized medicine
Highlights•The development of DNA aptamers parallels that of personalized medicine.•Both
aptamer-functionalized nanomaterials and DNA nanostructures have been developed.•They …
aptamer-functionalized nanomaterials and DNA nanostructures have been developed.•They …
Applications of aptamers in nanodelivery systems in cancer, eye and inflammatory diseases
Aptamers are an interesting class of molecules that have potential in many facets of human
health. They are characterized by high affinity and specificity to their targets, are small in …
health. They are characterized by high affinity and specificity to their targets, are small in …