Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial …
LA van Meeteren, M Thorikay, S Bergqvist… - Journal of Biological …, 2012 - ASBMB
Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1), a
transforming growth factor β (TGF-β) type I receptor, and endoglin, a TGF-β co-receptor, play …
transforming growth factor β (TGF-β) type I receptor, and endoglin, a TGF-β co-receptor, play …
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth
D Mitchell, EG Pobre, AW Mulivor, AV Grinberg… - Molecular cancer …, 2010 - AACR
Abstract Activin receptor–like kinase-1 (ALK1) is a type I, endothelial cell–specific member of
the transforming growth factor-β superfamily of receptors known to play an essential role in …
the transforming growth factor-β superfamily of receptors known to play an essential role in …
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
ALK1 is an endothelial-specific type I receptor of the TGFβ receptor family whose
heterozygous mutations cause hereditary hemorrhagic telangiectasia type 2. Although …
heterozygous mutations cause hereditary hemorrhagic telangiectasia type 2. Although …
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
M Scharpfenecker, M van Dinther, Z Liu… - Journal of cell …, 2007 - journals.biologists.com
Genetic studies in mice and humans have shown that the transforming growth factor-β (TGF-
β) type-I receptor activin receptor-like kinase 1 (ALK1) and its co-receptor endoglin play an …
β) type-I receptor activin receptor-like kinase 1 (ALK1) and its co-receptor endoglin play an …
Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK) 1 function
Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical
setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular …
setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular …
Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium
Y Yao, M Jumabay, A Ly, M Radparvar… - Blood, The Journal …, 2012 - ashpublications.org
The importance of morphogenetic proteins (BMPs) and their antagonists in vascular
development is increasingly being recognized. BMP-4 is essential for angiogenesis and is …
development is increasingly being recognized. BMP-4 is essential for angiogenesis and is …
Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies
DD Hu-Lowe, E Chen, L Zhang, KD Watson… - Cancer research, 2011 - AACR
Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an
important role in vascular development, remodeling, and pathologic angiogenesis. Here we …
important role in vascular development, remodeling, and pathologic angiogenesis. Here we …
A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma
E Tillet, M Ouarné, A Desroches-Castan… - Journal of Biological …, 2018 - ASBMB
Bone morphogenetic protein 9 (BMP9) and BMP10 are the two high-affinity ligands for the
endothelial receptor activin receptor-like kinase 1 (ALK1) and are key regulators of vascular …
endothelial receptor activin receptor-like kinase 1 (ALK1) and are key regulators of vascular …
Bone morphogenetic protein-9 is a circulating vascular quiescence factor
L David, C Mallet, M Keramidas, N Lamandé… - Circulation …, 2008 - Am Heart Assoc
Angiogenesis is a complex process, requiring a finely tuned balance between numerous
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial …
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial …
Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy
LJAC Hawinkels, A Garcia de Vinuesa… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Formation of blood vessels from pre-existing ones, also termed angiogenesis,
is of crucial importance for the outgrowth of tumours beyond 1–2 mm3. Therefore, anti …
is of crucial importance for the outgrowth of tumours beyond 1–2 mm3. Therefore, anti …