Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1), a
transforming growth factor β (TGF-β) type I receptor, and endoglin, a TGF-β co-receptor, play …

Abstract Activin receptor–like kinase-1 (ALK1) is a type I, endothelial cell–specific member of
the transforming growth factor-β superfamily of receptors known to play an essential role in …

ALK1 is an endothelial-specific type I receptor of the TGFβ receptor family whose
heterozygous mutations cause hereditary hemorrhagic telangiectasia type 2. Although …

Genetic studies in mice and humans have shown that the transforming growth factor-β (TGF-
β) type-I receptor activin receptor-like kinase 1 (ALK1) and its co-receptor endoglin play an …

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical
setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular …

The importance of morphogenetic proteins (BMPs) and their antagonists in vascular
development is increasingly being recognized. BMP-4 is essential for angiogenesis and is …

Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1) plays an
important role in vascular development, remodeling, and pathologic angiogenesis. Here we …

Bone morphogenetic protein 9 (BMP9) and BMP10 are the two high-affinity ligands for the
endothelial receptor activin receptor-like kinase 1 (ALK1) and are key regulators of vascular …

Angiogenesis is a complex process, requiring a finely tuned balance between numerous
stimulatory and inhibitory signals. ALK1 (activin receptor like-kinase 1) is an endothelial …

Introduction: Formation of blood vessels from pre-existing ones, also termed angiogenesis,
is of crucial importance for the outgrowth of tumours beyond 1–2 mm3. Therefore, anti …