Regulation of voltage‐gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders
Voltage‐gated potassium (KV) channels are key regulators of vascular smooth muscle
contractility and vascular tone, and thus have major influence on the microcirculation. KV …
contractility and vascular tone, and thus have major influence on the microcirculation. KV …
Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure
The endothelium is a critical regulator of vascular tone, and dysfunction of the endothelium
contributes to numerous cardiovascular pathologies. Recent studies suggest that apamin …
contributes to numerous cardiovascular pathologies. Recent studies suggest that apamin …
Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases
EA Ko, WS Park, AL Firth, N Kim, JXJ Yuan… - Progress in biophysics …, 2010 - Elsevier
In this review, the pathological alteration and clinical relevance of voltage-gated K+ (Kv)
channels and their specific regulation by protein kinase-dependent signaling in vascular …
channels and their specific regulation by protein kinase-dependent signaling in vascular …
Inward rectifier potassium (Kir2. 1) channels as end‐stage boosters of endothelium‐dependent vasodilators
Key points Increase in endothelial cell (EC) calcium activates calcium‐sensitive intermediate
and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization …
and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization …
Aging, ion channel expression, and vascular function
L Toro, J Marijic, K Nishimaru, Y Tanaka, M Song… - Vascular …, 2002 - Elsevier
Cardiovascular disease remains the leading cause of death in the United States, and aging
is one of the main risk factors for its development. Coronary arteries nurture the heart, but as …
is one of the main risk factors for its development. Coronary arteries nurture the heart, but as …
Human Coronary Arteriolar Dilation to Arachidonic Acid Depends on Cytochrome P-450 Monooxygenase and Ca2+-Activated K+ Channels
H Miura, DD Gutterman - Circulation research, 1998 - Am Heart Assoc
Endothelium-dependent hyperpolarization of vascular smooth muscle cells (VSMCs) plays a
crucial role in regulating vascular tone, especially in resistance vessels. It has been …
crucial role in regulating vascular tone, especially in resistance vessels. It has been …
EDHF: bringing the concepts together
R Busse, G Edwards, M Félétou, I Fleming… - Trends in …, 2002 - cell.com
Endothelial cells synthesize and release vasoactive mediators in response to various
neurohumoural substances (eg bradykinin or acetylcholine) and physical stimuli (eg cyclic …
neurohumoural substances (eg bradykinin or acetylcholine) and physical stimuli (eg cyclic …
Hyperpolarizing factors
J Quilley, D Fulton, JC McGiff - Biochemical pharmacology, 1997 - Elsevier
There is now overwhelming evidence for factors, other than nitric oxide (NO), that mediate
endothelium-dependent vasodilation by hyperpolarizing the underlying smooth muscle via …
endothelium-dependent vasodilation by hyperpolarizing the underlying smooth muscle via …
Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor (s)
Le facteur hyperpolarisant provenant de l'endothélium, ou EDHF, est défini comme la
substance non-monoxyde d'azote (NO) et non-prostacycline (PGI2) qui véhicule …
substance non-monoxyde d'azote (NO) et non-prostacycline (PGI2) qui véhicule …
Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone
A Ellis, CR Triggle - Canadian journal of physiology and …, 2003 - cdnsciencepub.com
Les points de vue sur le rôle des espèces oxygénées radicalaires (ROS) dans le système
vasculaire ont évolué au cours des dernières années; ainsi, les ROS ne sont plus …
vasculaire ont évolué au cours des dernières années; ainsi, les ROS ne sont plus …