Background and aims Pancreatic cancer is characterized by inadequate vascularization and
considerable tumor hypoxia is prevalent. However, whether hypoxia-inducible factor 1α (HIF …

Intratumoral hypoxia and paracrine insulin stimulate the expression of hypoxia inducible
factor-1α (HIF-1α) in pancreatic cancer cells. In the present studies, we investigated whether …

Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …

Simple Summary Hypoxia, or low oxygen levels within tumor tissue, presents a significant
challenge for the management of hepatocellular carcinoma (HCC). Hypoxic …

Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and
degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte …

Hypoxia‐inducible factors (HIFs) provoke adaptation to hypoxic stress occurring in rapidly
growing tumor tissues. Therefore, overexpression of HIF‐1 or HIF‐2 is a common feature in …

Aims To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by
hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor …

The aim of study was to discuss the correlation and regulatory mechanism of HIF-1 and miR-
191 expression in pancreatic tumor. The association between the miR-191 and the …

Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma
(HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy …

A local hypoxic microenvironment is one of the most important characteristics of solid
tumors. Hypoxia inducible factor-1α (HIF-1α) and Interleukin-8 (IL-8) activate tumor survival …