Abstract α‐Fetoprotein (AFP) has been proposed as a potential target forT‐cell‐based
immunotherapy for hepatocellular carcinoma (HCC), but the number of its epitopes that have …

Abstract Purpose: α-Fetoprotein (AFP) is a tumor-associated antigen in hepatocellular
carcinoma and is a target for the development of cancer vaccine. Four immunodominant …

Purpose: An existing immunological paradigm is that high concentrations of soluble protein
contribute to the maintenance of peripheral tolerance/ignorance to self protein. We tested …

The various immunological roles of human alpha-fetoprotein (HAFP), and its correlation with
hepatomas, that is, hepatocellular carcinomas (HCCs), are not often addressed together in …

Human α-fetoprotein (AFP) is a potentially important target for the immunotherapy of
hepatocellular carcinoma (HCC). AFP542–550 (GVALQTMKQ) is one of several HLA-A2. 1 …

We identified a series of immunodominant and subdominant epitopes from α fetoprotein
(AFP), restricted by HLA-A* 0201, which are recognized by the human T cell repertoire. The …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and is often
diagnosed at an advanced stage. We have investigated α-fetoprotein (AFP) as a tumor …

Background & Aims Levels of α-fetoprotein (AFP) are measured for surveillance and
diagnosis of hepatocellular carcinoma (HCC). We performed a phase 1 trial to evaluate the …

Abstract α fetoprotein (AFP)-derived peptide epitopes can be recognized by human T cells in
the context of MHC class I. We determined the identity of AFP-derived peptides, presented in …

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with limited
treatments. Asia has the highest HCC incidence rates; China accounts for over 50% of all …