G-quadruplex DNA: a potential target for anti-cancer drug design
In addition to the familiar duplex DNA, certain DNA sequences can fold into secondary
structures that are four-stranded; because they are made up of guanine (G) bases, such …
structures that are four-stranded; because they are made up of guanine (G) bases, such …
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution
J Dai, TS Dexheimer, D Chen, M Carver… - Journal of the …, 2006 - ACS Publications
We report the first G-quadruplex structure formed in the promoter region of the human bcl-2.
Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been …
Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been …
[PDF][PDF] Function and targeting of G-quadruplexes
HM Wong, L Payet, JL Huppert - curr. Opin. Mol. ther, 2009 - researchgate.net
Guanine-rich sequences of DNA and RNA may fold in vitro and in vivo into G-quadruplexes,
four-stranded helical structures held together by a guanine core. G-quadruplexes have …
four-stranded helical structures held together by a guanine core. G-quadruplexes have …
Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazole‒carbazole ligands
Recent studies support the idea that G-quadruplex structures in the promoter regions of
oncogenes and telomere DNA can serve as potential therapeutic targets in the treatment of …
oncogenes and telomere DNA can serve as potential therapeutic targets in the treatment of …
Non-duplex G-quadruplex DNA structure: a developing story from predicted sequences to DNA structure-dependent epigenetics and beyond
A Sengupta, SS Roy, S Chowdhury - Accounts of chemical …, 2020 - ACS Publications
Conspectus The story of the non-duplex DNA form known as the G-quadruplex (G4) has
traversed a winding path. From initial skepticism followed by debate to a surge in interest …
traversed a winding path. From initial skepticism followed by debate to a surge in interest …
Sequence, stability, and structure of G‐quadruplexes and their interactions with drugs
Y Chen, D Yang - Current protocols in nucleic acid chemistry, 2012 - Wiley Online Library
Although DNA is most widely known for its ability to store and pass along genetic
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …