Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk

T Kimpimaki, P Kulmala, K Savola… - The Journal of …, 2000 - academic.oup.com
To evaluate the emergence of diabetes-associated autoantibodies in young children and to
assess whether such antibodies can be used as surrogate markers of type 1 diabetes in …

Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general …

M Kukko, T Kimpimaki, S Korhonen… - The Journal of …, 2005 - academic.oup.com
This study characterized the dynamics of islet cell antibodies (ICA), insulin antibodies (IAA),
glutamic acid decarboxylase antibodies (GADA), and IA-2 antibodies (IA-2A) in 1006 …

Genetic risk determines the emergence of diabetes-associated autoantibodies in young children

A Kupila, P Keskinen, T Simell, S Erkkilä… - Diabetes, 2002 - Am Diabetes Assoc
Timing of onset of autoimmunity is a prerequisite for unmasking triggers and pathogenesis of
type 1 diabetes. We followed 4,590 consecutive newborns with 8 or 3% HLA-DQB1 …

Stability of autoantibodies and their relation to genetic and metabolic markers of Type I diabetes in initially unaffected schoolchildren

P Kulmala, J Rahko, K Savola, P Vähäsalo, R Veijola… - Diabetologia, 2000 - Springer
Aims/hypothesis. To study temporal changes in positivity for autoantibodies associated with
Type I (insulin-dependent) diabetes mellitus and the relations between these antibodies …

Natural history of β-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population

T Kimpimaki, P Kulmala, K Savola… - The Journal of …, 2002 - academic.oup.com
The aim of this study was to evaluate the frequency and predictive value of diabetes-
associated autoantibodies, such as islet cell antibodies (ICA) and autoantibodies to insulin …

Young age and HLA markers enhance the risk of progression to type 1 diabetes in antibody-positive siblings of diabetic children

AM Yamamoto, I Deschamps, HJ Garchon… - Journal of …, 1998 - Elsevier
The contribution of autoantibodies, HLA markers and age to long-term estimates of risk of
type 1 diabetes were examined after a median of 11 years (range 7.5–14) during the follow …

Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study

K Savola, E Läärä, P Vähäsalo, P Kulmala… - Diabetes, 2001 - Am Diabetes Assoc
To study the dynamics of disease-associated humoral immune responses, we analyzed
autoantibodies to the IA-2 protein (IA-2A), glutamic acid decarboxylase (GADA), and insulin …

Patterns of β-cell autoantibody appearance and genetic associations during the first years of life

J Ilonen, A Hammais, AP Laine, J Lempainen… - Diabetes, 2013 - Am Diabetes Assoc
We analyzed demographic and genetic differences between children with various diabetes-
associated autoantibodies reflecting the autoimmune process. In a prospective birth cohort …

Autoantibodies to GAD, IA‐2 and insulin in ICA‐positive first‐degree relatives of children with type 1 diabetes: a comparison between parents and siblings

S Korhonen, MM Knip, P Kulmala… - Diabetes/metabolism …, 2002 - Wiley Online Library
Background Islet cell antibodies (ICA) represent a heterogenous group of autoantibodies to
diabetes‐associated antigens, including glutamic acid decarboxylase (GAD) and the IA‐2 …

[PDF][PDF] Identification of children with early onset and high incidence of anti-islet autoantibodies

DT Robles, GS Eisenbarth, T Wang, HA Erlich… - Clinical …, 2002 - academia.edu
Type 1A diabetes, formerly termed insulin-dependent diabetes mellitus (IDDM) is a
genetically complex disorder resulting from immune-mediated destruction of the insulin …