Logistic Classification Models for PH–Permeability Profile: Predicting Permeability Classes for the Biopharmaceutical Classification System
Permeability is used to describe and evaluate the absorption of drug substances in the
human gastrointestinal tract (GIT). Permeability is largely dependent on fluctuating pH that …
human gastrointestinal tract (GIT). Permeability is largely dependent on fluctuating pH that …
Integrating theoretical and experimental permeability estimations for provisional biopharmaceutical classification: Application to the WHO essential medicines
MÁ Cabrera‐Pérez, H Pham‐The… - … & Drug Disposition, 2018 - Wiley Online Library
The accuracy of the provisional estimation of the Biopharmaceutics Classification System
(BCS) is heavily influenced by the permeability measurement. In this study, several …
(BCS) is heavily influenced by the permeability measurement. In this study, several …
Application of data mining approach to identify drug subclasses based on solubility and permeability
B Gatarić, J Parojčić - Biopharmaceutics & Drug Disposition, 2019 - Wiley Online Library
Solubility and permeability are recognized as key parameters governing drug intestinal
absorption and represent the basis for biopharmaceutics drug classification. The …
absorption and represent the basis for biopharmaceutics drug classification. The …
[HTML][HTML] Trivariate linear regression and machine learning prediction of possible roles of efflux transporters in estimated intestinal permeability values of 301 disparate …
M Shimizu, R Hayasaka, Y Kamiya… - Biological and …, 2022 - jstage.jst.go.jp
A system for predicting apparent bidirectional permeability (P app) across Caco-2 cells of
diverse chemicals has been reported. The present study aimed to investigate the …
diverse chemicals has been reported. The present study aimed to investigate the …
Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability
S Winiwarter, F Ax, H Lennernäs, A Hallberg… - Journal of Molecular …, 2003 - Elsevier
Hydrogen bonding has been identified as an important parameter for describing drug
permeability. Recently, we derived models for predicting intestinal permeability using the …
permeability. Recently, we derived models for predicting intestinal permeability using the …
pH-permeability profiles for drug substances: Experimental detection, comparison with human intestinal absorption and modelling
The influence of pH on human intestinal absorption is frequently not considered in early
drug discovery studies in the modelling and subsequent prediction of intestinal absorption …
drug discovery studies in the modelling and subsequent prediction of intestinal absorption …
Permeability diagnosis model in drug discovery: a diagnostic tool to identify the most influencing properties for gastrointestinal permeability
J Wang, S Skolnik - Current Topics in Medicinal Chemistry, 2013 - ingentaconnect.com
Permeability is important in governing the ability of drug substances to transport across
gastrointestinal membrane and also crucial for proper drug distribution to pharmacological …
gastrointestinal membrane and also crucial for proper drug distribution to pharmacological …
Provisional Classification and in Silico Study of Biopharmaceutical System Based on Caco-2 Cell Permeability and Dose Number
H Pham-The, T Garrigues, M Bermejo… - Molecular …, 2013 - ACS Publications
Today, early characterization of drug properties by the Biopharmaceutics Classification
System (BCS) has attracted significant attention in pharmaceutical discovery and …
System (BCS) has attracted significant attention in pharmaceutical discovery and …
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery
MV Varma, I Gardner, SJ Steyn, P Nkansah… - Molecular …, 2012 - ACS Publications
The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a
basis for predicting the oral absorption of drugs. These concepts have been extended in the …
basis for predicting the oral absorption of drugs. These concepts have been extended in the …
Highly predictive and interpretable models for PAMPA permeability
H Sun, K Nguyen, E Kerns, Z Yan, KR Yu… - Bioorganic & medicinal …, 2017 - Elsevier
Cell membrane permeability is an important determinant for oral absorption and
bioavailability of a drug molecule. An in silico model predicting drug permeability is …
bioavailability of a drug molecule. An in silico model predicting drug permeability is …