The judicious use of antibiotics to combat infections in children relies upon appropriate
selection of an agent, dose and duration to maximise efficacy and to minimise toxicity …

Objectives There have been few clinical trials (CTs) on antibiotics that inform neonatal and
paediatric drug labelling. The rate of unlicensed and off-label prescribing in paediatrics …

Background: β-lactams are among the most frequently prescribed antibiotics for the
treatment of neonatal sepsis. Survival of extremely preterm neonates necessitates an …

Objectives Wide variations in antibiotic use in very preterm infants have been reported
across centres despite similar rates of infection. We describe 10 year trends in use of …

Background Pharmacokinetic (PK) data underlying paediatric penicillin dosing remain
limited, especially in critical care. Objectives The primary objective of the Neonatal and …

Optimizing the use of antibiotics has become mandatory, particularly for the pediatric
population where limited options are currently available. Selecting the dosing strategy may …

Objectives In the heterogeneous group of preterm and term neonates, gentamicin and
tobramycin are mainly dosed according to empirical guidelines, after which therapeutic drug …

Introduction: For safe and effective use of antibacterial agents in neonates, specific
knowledge on the pharmacokinetics (PK) and its covariates is needed. This necessitates a …

Advancing our understanding of the evidence behind paediatric antimicrobial therapeutic
regimens is essential to improve both clinical outcomes and patient safety. Using a …

Amoxicillin is widely used to treat bacterial infections in neonates. However, considerable
intercenter variability in dosage regimens of antibiotics exists in clinical practice. The …