Introduction Severe infections continue to impose a major burden on critically ill children and
mortality rates remain stagnant. Outcomes rely on accurate and timely delivery of …

New initiatives have been introduced in Europe and the USA to encourage more rapid
development of antibiotics. The need to ensure these new antibiotics can be safely used in …

Neonatal sepsis still remains a significant cause of morbidity and mortality, prolonged
hospitalization, and increased medical costs. Early-and late-onset sepsis often presents with …

Rational dosing of antibiotics in neonates should be based on pharmacokinetic (PK)
parameters assessed in specific populations. PK studies of neonates are hampered by the …

Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the
emergence of resistance species and protect patients from the side effects of unnecessary …

Purpose Incorrect dosage was the most common type of medication errors in neonate
patients. Different dosing recommendations from common reference sources may have …

Once daily dosing of aminoglycosides has been introduced and validated in non-neonatal
patient cohorts. This is because aminoglycosides display peak concentration dependent …

Many antimicrobial medications may be administered to paediatric patients with a degree of
impunity because they are relatively non-toxic and have a wide therapeutic margin …

Methods: Relevant research questions were identified. An extensive electronic and manual
search methodology was used. Potentially eligible articles were screened for eligibility. The …

Objective Determine impact of using delivery criteria to initiate antibiotics among very low
birth weight (VLBW) and extremely low birth weight (ELBW) infants. Study design Single site …