Molecular classification of hepatocellular carcinoma: potential therapeutic implications
N Goossens, X Sun, Y Hoshida - Hepatic oncology, 2015 - Taylor & Francis
Genomic profiling of hepatocellular carcinoma (HCC) tumors has elucidated recurrent
molecular aberrations common or specific to disease etiology, patient race or geographic …
molecular aberrations common or specific to disease etiology, patient race or geographic …
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
JS Lee, J Heo, L Libbrecht, IS Chu, P Kaposi-Novak… - Nature medicine, 2006 - nature.com
The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests
that HCC may comprise several distinct biological phenotypes. These phenotypes may …
that HCC may comprise several distinct biological phenotypes. These phenotypes may …
[HTML][HTML] Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis
Genomic alterations driving tumorigenesis result from the interaction of environmental
exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is …
exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is …
[HTML][HTML] Genetics of hepatocellular carcinoma
A Teufel, F Staib, S Kanzler, A Weinmann… - World journal of …, 2007 - ncbi.nlm.nih.gov
The completely assembled human genome has made it possible for modern medicine to
step into an era rich in genetic information and high-throughput genomic analysis. These …
step into an era rich in genetic information and high-throughput genomic analysis. These …
[HTML][HTML] Epigenetics of hepatocellular carcinoma
In recent years, large scale genomics and genome-wide studies using comprehensive
genomic tools have reshaped our understanding of cancer evolution and heterogeneity …
genomic tools have reshaped our understanding of cancer evolution and heterogeneity …
Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management
Focal nodular hyperplasia (FNH), hepatocellular adenoma (HCA), and hepatocellular
carcinoma (HCC) compose hepatocellular neoplasms that occur in adults. These tumors …
carcinoma (HCC) compose hepatocellular neoplasms that occur in adults. These tumors …
[HTML][HTML] Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits
Background & Aims Human hepatocarcinogenesis is as a multi-step process starting from
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC) …
dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC) …
[HTML][HTML] Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium
D López-Terrada, R Alaggio, MT De Dávila… - Modern pathology, 2014 - Elsevier
Liver tumors are rare in children, and their diagnoses may be challenging particularly
because of the lack of a current consensus classification system. Systematic central …
because of the lack of a current consensus classification system. Systematic central …
[HTML][HTML] Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing
M Duan, J Hao, S Cui, DL Worthley, S Zhang, Z Wang… - Cell research, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a cancer of substantial morphologic, genetic and
phenotypic diversity. Yet we do not understand the relationship between intratumor …
phenotypic diversity. Yet we do not understand the relationship between intratumor …