Hepatocellular carcinoma is a chemoresistant cancer and a leading cause of cancer
mortality; however, the molecular mechanismsresponsible for the aggressive nature of this …

Epigenetic mechanisms maintain heritable changes in gene expression and chromatin
organization over many cell generations. Importantly, deregulated epigenetic mechanisms …

Liver cancer is the sixth-most-common cancer overall but the third-most-frequent cause of
cancer death. Among primary liver cancers, hepatocellular carcinoma (HCC), the major …

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Here, we
performed high-resolution copy-number analysis on 125 HCC tumors and whole-exome …

How bipotential hepatoblasts differentiate into hepatocytes and cholangiocytes remains
unclear. Here, using single‐cell transcriptomic analysis of hepatoblasts, hepatocytes, and …

Controlling both growth and differentiation of stem cells and their differentiated somatic
progeny is a challenge in numerous fields, from preclinical drug development to clinical …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumours worldwide.
The major aetiologies and risk factors for the development of HCC are well defined and …

In delineating the molecular pathogenesis of hepatocellular carcinoma (HCC), recent
experiments in mouse tumor models have revealed unexpected tumor-suppressing effects …

The major risk factors and etiological agents responsible for development of hepatocellular
carcinoma in humans have been identified and characterized. Among these are chronic …