Effect of ANG II was investigated in in vitro smooth muscle strips and in isolated smooth
muscle cells (SMC). Among different species, rat internal and sphincter (IAS) smooth muscle …

Studies were performed to compare the actions of Ang II in the internal anal sphincter (IAS)
vs. lower esophageal sphincter (LES) smooth muscles in vitro, in opossum and rabbit …

Previous studies have reported bimodal effects by angiotensin II (Ang II) in the rat internal
anal sphincter (IAS), a concentration-dependent contraction (at lower concentrations) and …

Background & Aims: The internal anal sphincter tone is important for anorectal continence.
This study examined the role of angiotensin II as a neurohumoral signal for the myogenic …

The myogenic control mechanisms that govern the basal tone in the internal anal sphincter
(IAS) are not known. The present studies determined the autocrine regulation of ANG II in …

Abstract Background: Angiotensin II (Ang II) is a well‐known activator of smooth muscle in
the vasculature but has been little explored with regard to intestinal wall muscular activity …

We examined the role of mitogen-activated protein kinase (p44/42 MAPK) in ANG II-induced
contraction of lower esophageal sphincter (LES) and internal anal sphincter (IAS) smooth …

Aim To analyse the effects of angiotensin II (Ang II) on the contractility of human sigmoid
colon, and to characterize the subtype (s) of receptor (s) involved and the related action …

The tonic smooth muscles of lower esophageal sphincter (LES) and internal anal sphincter
(IAS) are subject to modulation by the neurohumoral agents. We report that angiotensin …

The present study determined the effects of the angiotensin-converting enzyme (ACE)
inhibitor captopril and angiotensin II receptor subtype 1 (AT1-R) antagonist losartan on the …