The role of nitric oxide in erectile dysfunction: implications for medical therapy
AL Burnett - The Journal of Clinical Hypertension, 2006 - Wiley Online Library
Erectile dysfunction is a common, multifactorial disorder that is associated with aging and a
range of organic and psychogenic conditions, including hypertension …
range of organic and psychogenic conditions, including hypertension …
Nitric oxide and penile erectile function
N Toda, K Ayajiki, T Okamura - Pharmacology & therapeutics, 2005 - Elsevier
The discovery of nitric oxide (NO) as an intercellular messenger or neurotransmitter opened
a new era for identifying the important mechanisms underlying physiological and …
a new era for identifying the important mechanisms underlying physiological and …
Nitric oxide–cyclic GMP pathway with some emphasis on cavernosal contractility
IF Ghalayini - International journal of impotence research, 2004 - nature.com
Nitric oxide (NO) is formed from the conversion of L-arginine by nitric oxide synthase (NOS),
which exists in three isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) …
which exists in three isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) …
Role of nitric oxide in the physiology of erection
AL Burnett - Biology of reproduction, 1995 - academic.oup.com
Penile erection is understood to be a neurally regulated physiologic event, although the
underlying mechanisms have eluded characterization for more than a century. The classical …
underlying mechanisms have eluded characterization for more than a century. The classical …
The role of nitric oxide in penile erection
J Cartledge, S Minhas, I Eardley - Expert opinion on …, 2001 - Taylor & Francis
The functional state of the penis, flaccid or erect is governed by smooth muscle tone.
Sympathetic contractile factors maintain flaccidity whilst parasympathetic factors induce …
Sympathetic contractile factors maintain flaccidity whilst parasympathetic factors induce …
Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat
IS De Tejada - International journal of impotence research, 2004 - nature.com
Abstract Phosphodiesterase 5 (PDE5) inhibitors prevent the normal hydrolysis of cGMP. As
the resulting cGMP accumulation facilitates penile smooth muscle relaxation, PDE5 …
the resulting cGMP accumulation facilitates penile smooth muscle relaxation, PDE5 …
[引用][C] The role of nitric oxide in erectile function
JA Lugg, NF GONZÁLEZ‐CADAVID… - Journal of …, 1995 - Wiley Online Library
Normal erectile function depends on the ability of the penis to enlarge with blood and obtain
a rigidity sufficient for vaginal penetration. This penile tumescence results from three …
a rigidity sufficient for vaginal penetration. This penile tumescence results from three …
The nitric oxide signaling pathway in the penis
AL Burnett, B Musicki - Current pharmaceutical design, 2005 - ingentaconnect.com
It is widely accepted that nitric oxide plays an important role in the biology of the penis,
serving most familiarly as the agent responsible for penile erection. Early investigation in the …
serving most familiarly as the agent responsible for penile erection. Early investigation in the …
A review of the pathophysiology and novel treatments for erectile dysfunction
GF Lasker, JH Maley… - … in Pharmacological and …, 2010 - Wiley Online Library
Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70.
Treatment with PDE‐5 inhibitors is effective in the majority of men with ED. However, PDE‐5 …
Treatment with PDE‐5 inhibitors is effective in the majority of men with ED. However, PDE‐5 …
Potassium channels and erectile dysfunction
SL Archer - Vascular pharmacology, 2002 - Elsevier
The incidence of erectile dysfunction (ED), defined as the persistent inability to achieve or
maintain an erection sufficient for satisfactory sexual performance, increases with age and …
maintain an erection sufficient for satisfactory sexual performance, increases with age and …