Erectile dysfunction is a common, multifactorial disorder that is associated with aging and a
range of organic and psychogenic conditions, including hypertension …

The discovery of nitric oxide (NO) as an intercellular messenger or neurotransmitter opened
a new era for identifying the important mechanisms underlying physiological and …

Nitric oxide (NO) is formed from the conversion of L-arginine by nitric oxide synthase (NOS),
which exists in three isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) …

Penile erection is understood to be a neurally regulated physiologic event, although the
underlying mechanisms have eluded characterization for more than a century. The classical …

The functional state of the penis, flaccid or erect is governed by smooth muscle tone.
Sympathetic contractile factors maintain flaccidity whilst parasympathetic factors induce …

Abstract Phosphodiesterase 5 (PDE5) inhibitors prevent the normal hydrolysis of cGMP. As
the resulting cGMP accumulation facilitates penile smooth muscle relaxation, PDE5 …

Normal erectile function depends on the ability of the penis to enlarge with blood and obtain
a rigidity sufficient for vaginal penetration. This penile tumescence results from three …

It is widely accepted that nitric oxide plays an important role in the biology of the penis,
serving most familiarly as the agent responsible for penile erection. Early investigation in the …

Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70.
Treatment with PDE‐5 inhibitors is effective in the majority of men with ED. However, PDE‐5 …

The incidence of erectile dysfunction (ED), defined as the persistent inability to achieve or
maintain an erection sufficient for satisfactory sexual performance, increases with age and …