Long non-coding RNAs in vascular biology and disease

N Jaé, AW Heumüller, Y Fouani, S Dimmeler - Vascular pharmacology, 2019 - Elsevier
The advent of deep sequencing technologies recently unraveled the complexity of the
human genome: Although almost entirely transcribed, only a very minor part of our genome …

Roles of lncRNAs in cancer: Focusing on angiogenesis

KT Jin, JY Yao, XL Fang, H Di, YY Ma - Life sciences, 2020 - Elsevier
Approximately 98% of the human genome consists of non-coding sequences that are
classified into two classes by size: small non-coding RNAs (≤ 200 nucleotides) and long …

Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation

S Cremer, KM Michalik, A Fischer, L Pfisterer, N Jaé… - Circulation, 2019 - Am Heart Assoc
Background: The majority of the human genome comprises noncoding sequences, which
are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple …

[HTML][HTML] Long noncoding RNA: recent updates in atherosclerosis

H Li, H Zhu, J Ge - International journal of biological sciences, 2016 - ncbi.nlm.nih.gov
Long noncoding RNAs belong to a class of noncoding RNAs longer than 200 nucleotides
with the epigenetic regulation potential. As a novel molecular regulator, lncRNAs are often …

Crosstalk between long non-coding RNAs, micro-RNAs and mRNAs: deciphering molecular mechanisms of master regulators in cancer

E López-Urrutia, LP Bustamante Montes… - Frontiers in …, 2019 - frontiersin.org
Cancer is a complex disease, and its study requires deep understanding of several
biological processes and their regulation. It is an accepted fact that non-coding RNAs are …

Long non-coding RNAs in the atherosclerotic plaque

S Arslan, Ö Berkan, T Lalem, N Özbilüm, S Göksel… - Atherosclerosis, 2017 - Elsevier
Background and aims Genetic and environmental factors are important components of the
development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as …

Long non-coding RNAs in cardiac remodeling

S Shen, H Jiang, Y Bei, J Xiao, X Li - Cellular Physiology and …, 2017 - karger.com
Cardiac remodeling occurs after stress to the heart, manifested as pathological processes,
including hypertrophy and apoptosis of cardiomyocytes, dysfunction of vascular endothelial …

Involvement of long non-coding RNAs (lncRNAs) in tumor angiogenesis

J Teppan, DA Barth, F Prinz, K Jonas, M Pichler… - Non-coding RNA, 2020 - mdpi.com
Long non-coding RNAs (lncRNAs) are defined as non-protein coding transcripts with a
minimal length of 200 nucleotides. They are involved in various biological processes such …

Development of long noncoding RNA-based strategies to modulate tissue vascularization

J Fiedler, K Breckwoldt, CW Remmele… - Journal of the American …, 2015 - jacc.org
Background: Long noncoding ribonucleic acids (lncRNAs) are a subclass of regulatory
noncoding ribonucleic acids for which expression and function in human endothelial cells …

[HTML][HTML] Long noncoding RNAs, emerging and versatile regulators of tumor-induced angiogenesis

J Zhao, L Li, ZY Han, ZX Wang… - American journal of cancer …, 2019 - ncbi.nlm.nih.gov
Angiogenesis is an essential step in maintaining tumor growth and facilitating metastasis.
The regulatory mechanisms of tumor-induced angiogenesis are extremely complicated, and …