Understanding the reciprocal interplay between antibiotics and host immune system: how can we improve the anti-mycobacterial activity of current drugs to better …

HE Park, W Lee, MK Shin, SJ Shin - Frontiers in Immunology, 2021 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, remains a global
health threat despite recent advances and insights into host-pathogen interactions and the …

Mycobacterium tuberculosis: immune response, biomarkers, and therapeutic intervention

L Zhuang, L Yang, L Li, Z Ye, W Gong - MedComm, 2024 - Wiley Online Library
Although tuberculosis (TB) is an infectious disease, the progression of the disease following
Mycobacterium tuberculosis (MTB) infection is closely associated with the host's immune …

New tricks for old dogs: countering antibiotic resistance in tuberculosis with host‐directed therapeutics

TR Hawn, JA Shah, D Kalman - Immunological reviews, 2015 - Wiley Online Library
Despite the availability of M ycobacterium tuberculosis (Mtb) drugs for over 50 years,
tuberculosis (TB) remains at pandemic levels. New drugs are urgently needed for resistant …

Host-directed therapies to combat tuberculosis and associated non-communicable diseases

P Baindara - Microbial pathogenesis, 2019 - Elsevier
Mycobacterium tuberculosis (Mtb) has coevolved with a human host to evade and exploit the
immune system in multiple ways. Mtb is an enormously successful human pathogen that can …

Understanding metabolic regulation between host and pathogens: New opportunities for the development of improved therapeutic strategies against Mycobacterium …

JH Park, D Shim, KES Kim, W Lee… - Frontiers in Cellular and …, 2021 - frontiersin.org
Mycobacterium tuberculosis (Mtb) causes chronic granulomatous lung disease in humans.
Recently, novel strategies such as host-directed therapeutics and adjunctive therapies that …

Host-pathogen interaction as a novel target for host-directed therapies in tuberculosis

R Abreu, P Giri, F Quinn - Frontiers in immunology, 2020 - frontiersin.org
Tuberculosis (TB) has been a transmittable human disease for many thousands of years,
and M. tuberculosis is again the number one cause of death worldwide due to a single …

Host-directed therapy as a novel treatment strategy to overcome tuberculosis: targeting immune modulation

S Ahmed, R Raqib, GH Guðmundsson, P Bergman… - Antibiotics, 2020 - mdpi.com
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in
developing countries, presenting a major threat to the public health. The currently …

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

J Yang, L Zhang, W Qiao, Y Luo - MedComm, 2023 - Wiley Online Library
Tuberculosis (TB) remains a significant public health concern in the 21st century, especially
due to drug resistance, coinfection with diseases like immunodeficiency syndrome (AIDS) …

[HTML][HTML] Host-mycobacteria conflict: Immune responses of the host vs. the mycobacteria TLR2 and TLR4 ligands and concomitant host-directed therapy

KP Pattanaik, S Sengupta, BP Jit, R Kotak… - Microbiological …, 2022 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the most grievous
infectious diseases with long-term morbidity and unpredicted mortality rates globally. Thus …

Tweaking host immune responses for novel therapeutic approaches against Mycobacterium tuberculosis

A Roy, PK Agnivesh, S Sau, S Kumar, NP Kalia - Drug Discovery Today, 2023 - Elsevier
In TB, combat between the human host and Mycobacterium tuberculosis involves intricate
interactions with immune cells. M. tuberculosis has evolved a complex evasion system to …