The mitogen-activated protein kinases (MAPKs) play an important role in
ischemia/reperfusion (I/R) injury. Previous evidence suggests that p38 MAPK inhibition …

Background—Activation of p38 mitogen-activated protein kinase (MAPK) plays an important
role in apoptotic cell death. The role of p38 MAPK in myocardial injury caused by …

The MAPK family member p38 is activated in the heart after ischemia-reperfusion (I/R) injury.
However, the cardioprotective vs. proapoptotic effects associated with p38 activation in the …

p38 MAPK is activated during heart diseases that might associate with myocardial damage
and deterioration of cardiac function. In a rat model of myocardial injury, we have …

We report that SB203580 (SB), a specific inhibitor of p38-MAPK, protects pig myocardium
against ischemic injury in an in vivo model. SB was applied by local infusion into the …

Our aim was to test the hypothesis that cardioprotection achieved with ischemic
preconditioning (PC) involves increased activity of p38 mitogen-activated protein kinase …

p38 MAP kinase activation is known to be deleterious not only to mitochondria but also to
contractile function. Therefore, p38 MAP kinase inhibition therapy represents a promising …

Myocardial mitogen-activated protein kinases can be activated by ischemia and reperfusion,
and they may play important roles in the evolution of ischemic injury. Considerable work has …

p38 Mitogen-activated protein kinase (p38 MAPK) is activated by short episodes of
ischaemia-reperfusion as well as by sustained ischemia followed by reperfusion, Whether …

Objectives: The aim of this study was to examine the effect of the p38 mitogen-activated
protein kinase (MAPK) inhibitor, RWJ-67657 (RWJ), on left ventricular (LV) dysfunction and …