Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are first-line antidepressants but
require several weeks to elicit their actions. Chronic SSRI treatment induces desensitization …

Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment
of generalized anxiety disorder in Humans. However, because only few animal models …

Most depressed patients don't respond to their first drug treatment, and the reasons for this
treatment resistance remain enigmatic. Human studies implicate a polymorphism in the …

In this issue of Neuron, Richardson-Jones et al. report on a novel genetic approach to
conditionally and specifically dampen the function of the 5-HT 1A autoreceptor in mice to …

Rationale Identifying the etiological factors in anxiety and depression is critical to develop
more efficacious therapies. The inhibitory serotonin 1A receptors (5-HT 1A R) located on 5 …

The effects of serotonin (5-HT) on anxiety and depression are mediated by a number of 5-HT
receptors, including autoreceptors that act to inhibit 5-HT release. While the majority of …

Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been
thought to be central in the therapeutic action of antidepressant drugs. However, besides …

Most preclinical studies investigating the effects and the mechanism of action of
antidepressants have been performed in naive rodents. This is inappropriate because …

We used knockout mice and receptor antagonist strategies to investigate the contribution of
the serotonin (5‐hydroxytryptamine, 5‐HT) 1B receptor subtype in mediating the effects of …

Major depressive disorder (MDD) is the most prevalent mental illness contributing to global
disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line …