Background and Purpose—Small extracellular vesicles (sEVs) obtained from mesenchymal
stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral …

A stroke is a focal cerebral insult that frequently causes severe neurological deficit and
mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells …

Despite the various mechanisms that involved in the pathogenesis of Alzheimer's disease
(AD), neuronal damage and synaptic dysfunction are the key events leading to cognition …

Stem cell-based therapy is a promising approach for treating a variety of disorders, including
acute brain insults and neurodegenerative diseases. Stem cells such as mesenchymal stem …

Extracellular vesicles (EVs) secreted by cells present an attractive strategy for developing
new therapies, but progress in the field is limited by several issues: The quality of the EVs …

Vascular endothelial growth factor (VEGF) promotes neurogenesis in the adult
hippocampus, but the way in which this process occurs in the Alzheimer's disease (AD) …

Accumulating proofs signify that pleiotropic effects of mesenchymal stromal cells (MSCs) are
not allied to their differentiation competencies but rather are mediated mainly by the …

Tissue-resident stem cell senescence leads to stem cell exhaustion, which is a major cause
of physiological and pathological ageing. Stem cell-derived extracellular vesicles (SC-EVs) …

Extracellular vesicles (EVs)-based cell-free therapy, particularly stem cell-derived
extracellular vesicles (SC-EVs), offers new insights into treating a series of neurological …

Amyloid beta (Aβ) aggregation and tau hyper phosphorylation (p-tau) are key molecular
factors in Alzheimer's disease (AD). The abnormal formation and accumulation of Aβ and p …