Brain infiltration of peripheral immune cells and their interactions with brain-resident cells
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …

Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …

Neuroinflammation is a major contributor to disease progression in Alzheimer's disease
(AD) and is characterized by the activity of brain resident glial cells, in particular microglia …

An interaction network exists among cells within the brain, maintaining brain homeostasis
and ensuring its functional plasticity. In addition to neurons, participating cells include …

Background The immune cell compartment of the mammalian brain changes dramatically
and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the …

In the naïve mouse brain, microglia and astrocytes are the most abundant immune cells;
however, there is a complexity of other immune cells present including monocytes …

Neuroinflammation is considered one of the cardinal features of Alzheimer's disease (AD).
Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are …

Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as
antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ) …

Aging is associated with an increase in basal inflammation in the CNS and an overall
decline in cognitive function and poorer recovery following injury. Growing evidence …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …